Palmer Center for Chiropractic Research (PCCR) proposes to establish a 3 year multidisciplinary Developmental Center for the Study of Mechanisms and Effects of Chiropractic Manipulation (Center) to increase the level and quality of the ongoing research program, to advance scientific expertise and research infrastructure, and to support enhanced communication and partnering among 12 investigators at Palmer Chiropractic University, the University of Iowa, Kansas State University, State University of New York, and National University of Health Sciences. The Center will facilitate 4 synergistic research projects. The central scientific theme of the Center is focused on spinal manipulation (SM), low back pain (LBP), and the mechanisms of action of SM. The long range goal is to explore and understand the clinical role of SM and the physiological and biomechanical mechanisms of SM loads. Project 1 will study the biomechanical and neurological effects of vertebral loading on the facet joint capsule using an animal model. Project 2 will study the behavioral, biomechanical and biological effects of SM in a rat spine fixation model. Project 3 will explore variables that predict an important clinical effect of SM in patients with LBP, examine changes in biomechanical and physiological functions of patients undergoing SM, and biomechanically characterize 2 forms of SM. Project 4 will study the effect of vertebral loading on sympathetic nerve regulation in an animal model. Projects will be supported by the Data Management and Biostatistics Core, the Biomechanics Core and the Administration Core. Investigators will use pilot data to submit competitive grant applications to NIH, and will provide research training experiences for future CAM investigators. The developmental Center will build on and extend the successful recent history of the NIH supported, Consortial Center for Chiropractic Research at PCCR. It will provide the focus and direction to synergistically increase the """"""""critical mass"""""""" of personnel and resources to address an important unmet public health need.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AT002006-03
Application #
6904452
Study Section
Special Emphasis Panel (ZAT1-DB (10))
Program Officer
Weber, Wendy J
Project Start
2003-09-22
Project End
2008-05-31
Budget Start
2005-06-01
Budget End
2008-05-31
Support Year
3
Fiscal Year
2005
Total Cost
$672,687
Indirect Cost
Name
Palmer College of Chiropractic
Department
Type
Other Domestic Higher Education
DUNS #
075845834
City
Davenport
State
IA
Country
United States
Zip Code
52803
Goertz, Christine M; Salsbury, Stacie A; Vining, Robert D et al. (2016) Effect of Spinal Manipulation of Upper Cervical Vertebrae on Blood Pressure: Results of a Pilot Sham-Controlled Trial. J Manipulative Physiol Ther 39:369-80
Xia, Ting; Long, Cynthia R; Gudavalli, Maruti R et al. (2016) Similar Effects of Thrust and Nonthrust Spinal Manipulation Found in Adults With Subacute and Chronic Low Back Pain: A Controlled Trial With Adaptive Allocation. Spine (Phila Pa 1976) 41:E702-9
Pickar, J G; Bolton, P S (2012) Spinal manipulative therapy and somatosensory activation. J Electromyogr Kinesiol 22:785-94
Cao, Dong-Yuan; Khalsa, Partap S; Pickar, Joel G (2009) Dynamic responsiveness of lumbar paraspinal muscle spindles during vertebral movement in the cat. Exp Brain Res 197:369-77
Cao, Dong-Yuan; Pickar, Joel G; Ge, Weiginq et al. (2009) Position sensitivity of feline paraspinal muscle spindles to vertebral movement in the lumbar spine. J Neurophysiol 101:1722-9
Owens Jr, Edward F; DeVocht, James W; Gudavalli, M Ram et al. (2007) Comparison of posteroanterior spinal stiffness measures to clinical and demographic findings at baseline in patients enrolled in a clinical study of spinal manipulation for low back pain. J Manipulative Physiol Ther 30:493-500
Owens Jr, Edward F; DeVocht, James W; Wilder, David G et al. (2007) The reliability of a posterior-to-anterior spinal stiffness measuring system in a population of patients with low back pain. J Manipulative Physiol Ther 30:116-23