We propose a patient safety CERT focused on the theme of Tools for Optimizing Medication Safety (TOPMEDS). The long term goal is to improve patient safety by developing and refining tools for safer medication use. The short term objective is to develop, test, deploy and disseminate tools and training materials in four key areas: statistical methods for large-scale studies of comparative drug safety and effectiveness, opioid prescribing and dosing for acute pain, methods for preventing and detecting drug name confusion errors, and patient-centered, language concordant drug information. We will carry out studies with the following specific aims: 1. Develop and apply a multivariate, person-time logistic regression model for large-scale adverse drug event screening. 2. Improve the safety and effectiveness of inpatient acute pain care by developing and validating a novel, web-based simulator to train prescribers in the proper selection and dosing of opioids. 3. Refine a standard battery of tests for pre-market safety screening of drug names, and develop and test methods for preventing and detecting drug name confusion errors using electronic medical records. 4. Rigorously evaluate a low literacy strategy for promoting safe and effective prescription medication use among English and Spanish-speaking patients in an urban primary care setting. Together the projects address all five of the programmatic interest areas: comparative effectiveness, patient safety, development of tools, health care system interventions, and translation into policy or practice. UIC will host the center, with collaborators at Rush Universit Medical Center, Northwestern University, University of Chicago, the Brigham and Women's Hospital, Discerning Systems, Inc., the Institute for Safe Medication Practices, and the National Patient Safety Foundation. Our investigators are national and international leaders in statistics (Robert Gibbons), health literacy (Michael Wolf), drug name confusion (Bruce Lambert), health information technology (Gordon Schiff, Bill Galanter), pain care (Robert McNutt and Diana Wilkie) medication error prevention (Michael Cohen) and patient safety (Tim McDonald, Diane Pinakiewicz).

Public Health Relevance

Patients are not as safe as they should be. Medication errors and inappropriate use of medicines, by health professionals and patients, cause a great deal of harm. The proposed research will make patients safer by developing and sharing tools for safer medication use, including tools for detecting drug risks, for training young doctors, for preventin medication errors and for making drug information easier to understand.

Agency
National Institute of Health (NIH)
Institute
Agency for Healthcare Research and Quality (AHRQ)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19HS021093-01
Application #
8265048
Study Section
Special Emphasis Panel (ZHS1-HSR-X (03))
Program Officer
Kelly, Carmen
Project Start
2011-09-30
Project End
2016-08-31
Budget Start
2011-09-30
Budget End
2012-08-31
Support Year
1
Fiscal Year
2011
Total Cost
Indirect Cost
Name
University of Illinois at Chicago
Department
Administration
Type
Schools of Pharmacy
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Schroeder, Scott R; Salomon, Meghan M; Galanter, William L et al. (2017) Cognitive tests predict real-world errors: the relationship between drug name confusion rates in laboratory-based memory and perception tests and corresponding error rates in large pharmacy chains. BMJ Qual Saf 26:395-407
Kannampallil, Thomas; Galanter, William L; Falck, Suzanne et al. (2016) Characterizing the pain score trajectories of hospitalized adult medical and surgical patients: a retrospective cohort study. Pain 157:2739-2746
Lambert, Bruce L; Bhaumik, Runa; Zhao, Weihan et al. (2016) Detection and prediction limits for identifying highly confusable drug names from experimental data. J Biopharm Stat 26:365-85
Przytula, Kamila; Bailey, Stacy Cooper; Galanter, William L et al. (2015) A primary care, electronic health record-based strategy to promote safe drug use: study protocol for a randomized controlled trial. Trials 16:17
McMullen, Carmit K; Safford, Monika M; Bosworth, Hayden B et al. (2015) Patient-centered priorities for improving medication management and adherence. Patient Educ Couns 98:102-10
Gibbons, Robert D; Coca Perraillon, Marcelo; Hur, Kwan et al. (2015) Antidepressant treatment and suicide attempts and self-inflicted injury in children and adolescents. Pharmacoepidemiol Drug Saf 24:208-14
Wolf, Michael S; Bailey, Stacy C; Serper, Marina et al. (2014) Comparative effectiveness of patient-centered strategies to improve FDA medication guides. Med Care 52:781-9
Galanter, William L; Bryson, Michelle L; Falck, Suzanne et al. (2014) Indication alerts intercept drug name confusion errors during computerized entry of medication orders. PLoS One 9:e101977
Walton, Surrey M; Rash, Christine; Lambert, Bruce L et al. (2014) A case study in generic drug use: should there be risk adjustment in incentive payments for the use of generic medications? J Manag Care Spec Pharm 20:1093-9
Qato, Dima M; Daviglus, Martha L; Wilder, Jocelyn et al. (2014) 'Pharmacy deserts' are prevalent in Chicago's predominantly minority communities, raising medication access concerns. Health Aff (Millwood) 33:1958-65

Showing the most recent 10 out of 11 publications