) Duke University, Emory University and the University of North Carolina at Chapel Hill (UNC) are applying to become members of the Cancer Genetics Network. We will combine our patient resources, establish cooperative clinical practices and accrue subjects to the common Network registry. The clinical resources of our Network Center are very large; together with our affiliates, our institutional networks care for more than 20,000 cancer cases each year. Our institutions have unique access to population-based registries, including state cancer registries, populations taking part in genetic and molecular epidemiology studies and SEER registries. We draw from both urban and rural communities and our patient population is directly comparable to the ethnic profile southeastern United States. Our Carolina and Georgia Network Center brings a breadth of experience in human genetics to the process of planning national Network projects. Emory University has a nationally recognized program of Medical Genetics and a regional Medical Genetics Laboratory for specialized molecular and genetic testing. The University of North Carolina has a remarkable School of Public Health, an active outreach program to foster health care and several useful population-based registries of cancer. Duke has vast clinical operations and a basic science faculty with expertise in genomics, statistical genetics and molecular biology. Our Center already has captured large populations of patients with well-documented family histories of cancer. We are conducting a clinic trial of genetic counseling strategies and have on-site, low cost testing facilities for breast cancer susceptibility. Our investigators have developed case ascertainment methods to capture patients from our registries for entry in research studies. We have received substantial institutional support for genetic testing, clinical cancer genetic services and our educational programs. The people in our Center will contribute to all aspects of Network planning and are ready to modify our approaches to align our Center with consensus reached by the Network planning activities. Within this application, we propose to take advantage of our expertise and resources to ascertain registrants by augmenting referral services and by piloting the selective use of our unique registries.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
3U24CA078157-05S3
Application #
6805393
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Kasten-Sportes, Carol H
Project Start
1998-08-01
Project End
2004-07-31
Budget Start
2002-08-01
Budget End
2004-07-31
Support Year
5
Fiscal Year
2003
Total Cost
$768,327
Indirect Cost
Name
Duke University
Department
Surgery
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Skates, Steven J; Greene, Mark H; Buys, Saundra S et al. (2017) Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk - Combined Results from Two Screening Trials. Clin Cancer Res 23:3628-3637
Hill, Deirdre A; Horick, Nora K; Isaacs, Claudine et al. (2014) Long-term risk of medical conditions associated with breast cancer treatment. Breast Cancer Res Treat 145:233-43
Ziogas, Argyrios; Horick, Nora K; Kinney, Anita Y et al. (2011) Clinically relevant changes in family history of cancer over time. JAMA 306:172-8
Neklason, Deborah W; Done, Michelle W; Sargent, Nykole R et al. (2011) Activating mutation in MET oncogene in familial colorectal cancer. BMC Cancer 11:424
Skates, Steven J; Mai, Phuong; Horick, Nora K et al. (2011) Large prospective study of ovarian cancer screening in high-risk women: CA125 cut-point defined by menopausal status. Cancer Prev Res (Phila) 4:1401-8
Hoyo, Cathrine; Grubber, Janet; Demark-Wahnefried, Wendy et al. (2009) Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men. J Natl Med Assoc 101:711-6
Neklason, Deborah W; Kerber, Richard A; Nilson, David B et al. (2008) Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis. Cancer Res 68:8993-7
Tai, Yu Chuan; Domchek, Susan; Parmigiani, Giovanni et al. (2007) Breast cancer risk among male BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst 99:1811-4
Mori, Y; Yin, J; Rashid, A et al. (2001) Instabilotyping: comprehensive identification of frameshift mutations caused by coding region microsatellite instability. Cancer Res 61:6046-9
Elsas 2nd, L J; Trepanier, A (2000) Cancer genetics in primary care. When is genetic screening an option and when is it the standard of care? Postgrad Med 107:191-4, 197-200, 205-8