ECOG-ACRIN (EA) represents the merger of ECOG and ACRIN to form a cooperative group focused on practice-changing clinical and translational research across the cancer care continuum from cancer prevention and early detection, through the management of advanced disease and its impact. This application is to support the infrastructure and banking operations for one of the five NCI National Clinical Trials Network (NCTN) Biospecimen Banks. Together, the NCTN Banks will form an integrated network and will collaborate with each other and with affiliated NCTN Group Statistics and Data Management Centers, Operations Offices, other NCTN units, NCI-sponsored programs and investigators, and the NCI. The goal is to ensure the collection, storage, and distribution of well-annotated human biospecimens, procured from cancer patients participating in NCI-funded NCTN Phase III and large Phase II clinical treatment trials. EA's Specific Aims are: 1) To collect, process, store, catalog, and distribute malignant and non-malignant tissues, cells, blood, and other fluid specimens and their derivatives (DNA, RNA, and protein) from patients enrolled in EA clinical trials following the NCI's Best Practices for Biospecimen Resources and to link the specimens to relevant clinical, pathologic, and molecular data within the NCTN program; 2) To develop and utilize both routine and innovative biospecimen resources that will aid in the successful completion of NCTN-supported clinical trials based on integral biomarkers and of related correlative studies to promote the development of novel biomarker-driven personalized cancer therapeutic strategies; 3) To develop capabilities for performing classic and molecular methodologies on tissue, cell, blood, and other body fluid-based specimens from EA clinical trial patients, including planned future consolidation of specimen-based functions, and provide expert interpretation of the findings in close collaboration with the investigators leading the related NCTN-supported clinical trials; and 4) To assist investigators outside and within the NCTN to access biospecimens for research via IT Navigator and NCTN Biospecimen front door services, and to participate actively in, lead, and coordinate the activities of the NCI Grou Banking Committee (GBC), the NCI Experimental Therapeutics Clinical Trials Network (ETCTN), and other National Institutes of Health (NIH)/NCI-supported specimen banking organizations.

Public Health Relevance

The ECOG-ACRIN Central Biorepository and Pathology Facility and Leukemia Tissue Bank will receive, process, store and distribute high quality, well-annotated tissue specimens as well as blood and other biological fluids from patients participating in NCTN clinical trials. The specimens will encompass adult solid malignant and non-malignant tumors (e.g., tumors of the brain, breast, gastrointestinal tract, genitourinary trac, gynecologic/reproductive system, head and neck, skin, liver, lung, soft tissue, and thyroid gland) and hematologic malignancies (leukemia, lymphoma, and multiple myeloma).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
3U24CA196172-05S1
Application #
10148412
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Makhlouf, Hala
Project Start
2015-04-29
Project End
2020-08-31
Budget Start
2019-04-01
Budget End
2020-08-31
Support Year
5
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Ecog-Acrin Medical Research Foundation
Department
Type
DUNS #
078579855
City
Philadelphia
State
PA
Country
United States
Zip Code
19103
Moots, Paul L; O'Neill, Anne; Londer, Harold et al. (2018) Preradiation Chemotherapy for Adult High-risk Medulloblastoma: A Trial of the ECOG-ACRIN Cancer Research Group (E4397). Am J Clin Oncol 41:588-594
Marcelletti, John F; Sikic, Branimir I; Cripe, Larry D et al. (2018) Evidence of a role for functional heterogeneity in multidrug resistance transporters in clinical trials of P-glycoprotein modulation in acute myeloid leukemia. Cytometry B Clin Cytom :
Brown, Fiona C; Still, Eric; Koche, Richard P et al. (2018) MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia. Cancer Discov 8:478-497
Henderson, Tara O; Parsons, Susan K; Wroblewski, Kristen E et al. (2018) Outcomes in adolescents and young adults with Hodgkin lymphoma treated on US cooperative group protocols: An adult intergroup (E2496) and Children's Oncology Group (COG AHOD0031) comparative analysis. Cancer 124:136-144
Kashani-Sabet, Mohammed; Nosrati, Mehdi; Miller 3rd, James R et al. (2017) Prospective Validation of Molecular Prognostic Markers in Cutaneous Melanoma: A Correlative Analysis of E1690. Clin Cancer Res 23:6888-6892
Strickland, Stephen A; Sun, Zhuoxin; Ketterling, Rhett P et al. (2017) Independent Prognostic Significance of Monosomy 17 and Impact of Karyotype Complexity in Monosomal Karyotype/Complex Karyotype Acute Myeloid Leukemia: Results from Four ECOG-ACRIN Prospective Therapeutic Trials. Leuk Res 59:55-64
Goldstein, Lori J; Zhao, Fengmin; Wang, Molin et al. (2017) A Phase I/II study of suberoylanilide hydroxamic acid (SAHA) in combination with trastuzumab (Herceptin) in patients with advanced metastatic and/or local chest wall recurrent HER2-amplified breast cancer: a trial of the ECOG-ACRIN Cancer Research Group ( Breast Cancer Res Treat 165:375-382
Leng, Shuguang; Wu, Guodong; Klinge, Donna M et al. (2017) Gene methylation biomarkers in sputum as a classifier for lung cancer risk. Oncotarget 8:63978-63985
Butterfield, Lisa H; Zhao, Fengmin; Lee, Sandra et al. (2017) Immune Correlates of GM-CSF and Melanoma Peptide Vaccination in a Randomized Trial for the Adjuvant Therapy of Resected High-Risk Melanoma (E4697). Clin Cancer Res 23:5034-5043
Kalinsky, Kevin; Lee, Sandra; Rubin, Krista M et al. (2017) A phase 2 trial of dasatinib in patients with locally advanced or stage IV mucosal, acral, or vulvovaginal melanoma: A trial of the ECOG-ACRIN Cancer Research Group (E2607). Cancer 123:2688-2697

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