Abstract

North Carolina Central University is responding to the NIH-National Institute on Drug Abuse and Office of Research on Minority Health initiative entitled HBCU Research Scientist Award. The proposed NCCU drug abuse research program in collaboration with Wake Forest University School of Medicine, will focus on molecular mechanisms of drug-cell interaction, seeking to understand the molecular correlates of addictive behavior. The program will be housed in the new Biomedical/Biotechnology Research Institute. Working with NIDA and ORMH, NCCU will address the program goals and support the growth and development of drug abuse research by: assembling a panel of scientists external to NCCU that could serve as a drug abuse research advisory committee: identifying and recruiting an experienced individual generally recognized as an accomplished drug abuse research scientist: establishing formal linkages with scientists at the drug abuse research center located at Wake Forest University School Medicine, located approximately 110 miles from NCCU: cost effective assembly and training of a high quality team of scientists to conduct drug abuse research at NCCU: and serving as a catalyst to enhance public awareness, particularly among the minority community, of the behavioral and public health consequences of drug addiction.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24DA012385-05
Application #
6656392
Study Section
Special Emphasis Panel (ZDA1-WXG-F (26))
Program Officer
Thadani, Pushpa
Project Start
1998-09-30
Project End
2005-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
5
Fiscal Year
2003
Total Cost
$500,000
Indirect Cost

  Institution

Name
North Carolina Central University
Department
Type
Organized Research Units
DUNS #
072026321
City
Durham
State
NC
Country
United States
Zip Code
27707

  Publications

Balas, Laurence; Durand, Thierry; Saha, Sattyabrata et al. (2009) Total synthesis of photoactivatable or fluorescent anandamide probes: novel bioactive compounds with angiogenic activity. J Med Chem 52:1005-17
Carney, Skyla T; Lloyd, Michael L; MacKinnon, Shanta E et al. (2009) Cannabinoid regulation of nitric oxide synthase I (nNOS) in neuronal cells. J Neuroimmune Pharmacol 4:338-49
Gerald, Tonya M; Howlett, Allyn C; Ward, Gregg R et al. (2008) Gene expression of opioid and dopamine systems in mouse striatum: effects of CB1 receptors, age and sex. Psychopharmacology (Berl) 198:497-508
Jones, Jenelle D; Carney, Skyla T; Vrana, Kent E et al. (2008) Cannabinoid receptor-mediated translocation of NO-sensitive guanylyl cyclase and production of cyclic GMP in neuronal cells. Neuropharmacology 54:23-30
Grace, Christy R R; Cowsik, Sudha M; Shim, Joong-Youn et al. (2007) Unique helical conformation of the fourth cytoplasmic loop of the CB1 cannabinoid receptor in a negatively charged environment. J Struct Biol 159:359-68
Ward, Gregg R; Franklin, Steven O; Gerald, Tonya M et al. (2007) Glucocorticoids plus opioids up-regulate genes that influence neuronal function. Cell Mol Neurobiol 27:651-60
Mukhopadhyay, Somnath; Tulis, David A (2007) Endocannabinoid regulation of matrix metalloproteinases: implications in ischemic stroke. Cardiovasc Hematol Agents Med Chem 5:311-8
McCollum, LaTronya; Howlett, Allyn C; Mukhopadhyay, Somnath (2007) Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells. J Pharmacol Exp Ther 321:930-7
Anavi-Goffer, Sharon; Fleischer, Daniel; Hurst, Dow P et al. (2007) Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms. J Biol Chem 282:25100-13
Mukhopadhyay, Somnath; Das, Sucharita; Williams, Evelyn A et al. (2006) Lipopolysaccharide and cyclic AMP regulation of CB(2) cannabinoid receptor levels in rat brain and mouse RAW 264.7 macrophages. J Neuroimmunol 181:82-92

Showing the most recent 10 out of 20 publications