Abstract

The National NeuroAIDS Tissue Consortium (NNTC) is a collective tissue and data resourcing program in which the Texas NeuroAIDS Research Center (TNRC; B. Gelman, PI) has continuously participated as a contributing site since Inception In 1998. The NNTC's purpose Is to collect and distribute critical clinical data and tissue specimens from longitudinally-tracked HIV-infected Individuals at high risk for HIV-associated neurocognitive disorders (HAND) to support Innovative and transformative Investigator-Initiated research In the NeuroAIDS community at large. Beyond supplying tissue specimens the NNTC provides researchers access to relevant in vivo biomarkers, viral loads, gene expression data, neuropathological changes, and associated HAND cognitive status. This enables clinical and basic science-level researchers to incorporate these critical measures Into Investigations of the mechanisms driving HAND, HIV-associated pathological effects of HIV Infection, or potential HAND therapeutic targets. The broad aim of the TNRC application is to continue to provide such resources derived from locally-recruited (Texan) HIV cohorts and to further develop this local resource and the collective strength of the NNTC in addressing the currently changing and future resource needs of the NeuroAIDS community In the HAART era. The TNRC site focuses particularly on resource collection and utilization strategies that fully exploit their research value. The application for continued support to operate the clinic site addresses all aspects of the general operating procedures. Included are recruiting practices, neuropsychological evaluations, substance use surveys, neuromedical protocols, autopsy procedure, and specimen repository management. Strategies to contribute to consortium goals and obtain synergy with the other units of the NNTC are proposed. Continued operation of TNRC will have a lasting and positive impact on the search for remedies for HAND, CNS aging, and other HIV- associated pathological conditions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
4U24MH100930-04
Application #
9062514
Study Section
Special Emphasis Panel (ZMH1)
Program Officer
Colosi, Deborah
Project Start
2013-05-01
Project End
2018-02-28
Budget Start
2016-03-01
Budget End
2017-02-28
Support Year
4
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
University of Texas Medical Br Galveston
Department
Pathology
Type
Schools of Medicine
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555

  Publications

Alakkas, Aljoharah; Ellis, Ronald J; Watson, Caitlin Wei-Ming et al. (2018) White matter damage, neuroinflammation, and neuronal integrity in HAND. J Neurovirol :
Gill, Alexander J; Garza, Rolando; Ambegaokar, Surendra S et al. (2018) Heme oxygenase-1 promoter region (GT)n polymorphism associates with increased neuroimmune activation and risk for encephalitis in HIV infection. J Neuroinflammation 15:70
Guha, Debjani; Mukerji, Shibani S; Chettimada, Sukrutha et al. (2018) CSF extracellular vesicles and neurofilament light protein as biomarkers of CNS injury in HIV-infected patients on antiretroviral therapy. AIDS :
Anderson, Ariana E; Jones, Jacob D; Thaler, Nicholas S et al. (2018) Intraindividual variability in neuropsychological performance predicts cognitive decline and death in HIV. Neuropsychology 32:966-972
Gelman, Benjamin B; Endsley, Janice; Kolson, Dennis (2018) When do models of NeuroAIDS faithfully imitate ""the real thing""? J Neurovirol 24:146-155
Premeaux, Thomas A; D'Antoni, Michelle L; Abdel-Mohsen, Mohamed et al. (2018) Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals. J Neurovirol :
Chettimada, Sukrutha; Lorenz, David R; Misra, Vikas et al. (2018) Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy. Sci Rep 8:7227
Stern, Anna L; Ghura, Shivesh; Gannon, Patrick J et al. (2018) BACE1 Mediates HIV-Associated and Excitotoxic Neuronal Damage Through an APP-Dependent Mechanism. J Neurosci 38:4288-4300
Soontornniyomkij, Virawudh; Umlauf, Anya; Soontornniyomkij, Benchawanna et al. (2018) Association of antiretroviral therapy with brain aging changes among HIV-infected adults. AIDS 32:2005-2015
Marquine, María J; Heaton, Anne; Johnson, Neco et al. (2018) Differences in Neurocognitive Impairment Among HIV-Infected Latinos in the United States. J Int Neuropsychol Soc 24:163-175

Showing the most recent 10 out of 57 publications