The projected need for Indian rhesus macaques for AIDS-related research continues to exceed availability. Given the increase in nonhuman primate use for AIDS-related opportunistic infection research, and their projected use for research focused on emerging disease and agents exploitable for bioterrorism, this shortage will likely continue for years to come. While source countries are a potentially important reserve of untapped production, the increasing difficulty of transporting nonhuman primates both internationally and domestically suggests relying on imports may provide only short term relief. Further, nonhuman primates with the level of genetic and microbial characterization prerequisite for many research models are currently not available from source country production resources. Domestic breeding programs managed to produce the well characterized animals necessary for cutting-edge research offer the best long-term solution for the current shortage of Indian-origin rhesus macaques for AIDS vaccine and pathogenesis studies. Investment in domestic breeding programs will also insure future availability. The comprehensive objective of this application is to increase the capacity of the ONPRC AIDS Research Expanded SPF Breeding Colony to provide genetically characterized Indian-origin rhesus macaques free of a broad number of enzootic and zoonotic agents to enhance the usefulness of the resource for cutting edge opportunistic agent and vaccine research.
The specific aims for accomplishing this objective are to a) maintain and continue to expand the ONPRC AIDS Research Expanded SPF Rhesus Macaque Breeding Colony to a target population of 100adult breeder females capable of producing 35 surplus animals annually for research use, b) optimize the potential usefulness of rhesus macaques produced in the ONPRC AIDS Research Expanded SPF Breeding Colony for vaccine research by ensuring SPF status and managing the colony for the production of offspring of known parentage and genetic background that are MHC-defined, and c) improve infrastructure necessary to maintain the ONPRC AIDS Research Expanded SPF Rhesus Macaque Breeding Colony as a closed and protected resource. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
2U24RR018107-06
Application #
7322899
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Harding, John D
Project Start
2002-09-30
Project End
2012-08-31
Budget Start
2007-09-22
Budget End
2008-08-31
Support Year
6
Fiscal Year
2007
Total Cost
$872,503
Indirect Cost
Name
Oregon Health and Science University
Department
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Robinson, Bridget A; Estep, Ryan D; Messaoudi, Ilhem et al. (2012) Viral interferon regulatory factors decrease the induction of type I and type II interferon during rhesus macaque rhadinovirus infection. J Virol 86:2197-211
Robinson, Bridget A; O'Connor, Megan A; Li, He et al. (2012) Viral interferon regulatory factors are critical for delay of the host immune response against rhesus macaque rhadinovirus infection. J Virol 86:2769-79
Hansen, Scott G; Powers, Colin J; Richards, Rebecca et al. (2010) Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus. Science 328:102-6
Okoye, Afam; Park, Haesun; Rohankhedkar, Mukta et al. (2009) Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis. J Exp Med 206:1575-88
Murray, Shannon M; Picker, Louis J; Axthelm, Michael K et al. (2008) Replication in a superficial epithelial cell niche explains the lack of pathogenicity of primate foamy virus infections. J Virol 82:5981-5
Price, David A; Bitmansour, Arlene D; Edgar, John B et al. (2008) Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaques. J Immunol 180:269-80
Okoye, Afam; Meier-Schellersheim, Martin; Brenchley, Jason M et al. (2007) Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection. J Exp Med 204:2171-85
Picker, Louis J; Reed-Inderbitzin, Edward F; Hagen, Shoko I et al. (2006) IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates. J Clin Invest 116:1514-24
Margolin, David H; Saunders, Erika H; Bronfin, Benjamin et al. (2006) Germinal center function in the spleen during simian HIV infection in rhesus monkeys. J Immunol 177:1108-19
Murray, S M; Picker, L J; Axthelm, M K et al. (2006) Expanded tissue targets for foamy virus replication with simian immunodeficiency virus-induced immunosuppression. J Virol 80:663-70

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