The Biological Response Resource (BRR) will examined the interactions of exogenous and endogenous chemicals with our biological molecules as they are necessary for there to be a biological effect. One of the most important and practical reasons to include the biological response is that the vast majority of exposures are transient. The chemicals underlying exposures that occurred weeks, months, or years ago are long gone from the body. However, these past chemical exposures often leave molecular fingerprints of their presence. Whether this be damaged DNA, epigenetic modification, or protein adduct formation, the biological fingerprints may be able to provide information of these transient exposures of the past. Without the specific inclusion of the biological impact of exposures in the working definition of the exposome we are left with no way to assess prior exposures at a biological level. The overall goal of the Biological Response Resource BRR is to provide expertise and access to a suite of validated measures of biological responses. In order to offer maximal flexibility to potential users, our BRR is offering a wide array of assays that range from genomic and epigenomic offerings to measures of redox status, cytokine production, and pathway analysis. The goal will be pursued through the following objectives: Objective 1. To educate investigators on the benefits of biological assays available and assist in study design and sample optimization. Objective 2. To provide state-of-the-art measurements that assess the biological effects of, and susceptibility to, exposures on the human genome. Objective 3. To provide access to a variety of other indices of biological response, such as comprehensive profiling of redox state, multiplexed cytokine assessment, and microbiome characterization. Objective 4. To collaborate with the Untargeted Research Resource to identify biological responses that can be measured as part of the untargeted (metabolomics) analysis. Objective 5. To interface with the Developmental Research Resource and the Targeted Research Resource to identify biological markers which are highly associated with specific exposures. The Biological Response Resource will work with CHEAR clients, NEALE colleagues, and the entire CHEAR network to develop reliable and reproducible indices of environmentally-induced perturbations of biological systems.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Resource-Related Research Multi-Component Projects and Centers Cooperative Agreements (U2C)
Project #
1U2CES026560-01
Application #
9062183
Study Section
Special Emphasis Panel (ZES1-LWJ-J (UC))
Project Start
2015-09-30
Project End
2019-08-31
Budget Start
2015-09-01
Budget End
2016-08-31
Support Year
1
Fiscal Year
2015
Total Cost
$1,061,307
Indirect Cost
$369,067
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Wright, Robert O; Teitelbaum, Susan; Thompson, Claudia et al. (2018) The child health exposure analysis resource as a vehicle to measure environment in the environmental influences on child health outcomes program. Curr Opin Pediatr 30:285-291
Smirnov, Aleksandr; Jia, Wei; Walker, Douglas I et al. (2018) ADAP-GC 3.2: Graphical Software Tool for Efficient Spectral Deconvolution of Gas Chromatography-High-Resolution Mass Spectrometry Metabolomics Data. J Proteome Res 17:470-478
Chandler, Joshua D; Horati, Hamed; Walker, Douglas I et al. (2018) Determination of thiocyanate in exhaled breath condensate. Free Radic Biol Med 126:334-340
Frediani, Jennifer K; Naioti, Eric A; Vos, Miriam B et al. (2018) Arsenic exposure and risk of nonalcoholic fatty liver disease (NAFLD) among U.S. adolescents and adults: an association modified by race/ethnicity, NHANES 2005-2014. Environ Health 17:6
Hu, Xin; Chandler, Joshua D; Park, Soojin et al. (2018) Low-dose cadmium disrupts mitochondrial citric acid cycle and lipid metabolism in mouse lung. Free Radic Biol Med 131:209-217
Niedzwiecki, Megan M; Samant, Pradnya; Walker, Douglas I et al. (2018) Human Suction Blister Fluid Composition Determined Using High-Resolution Metabolomics. Anal Chem 90:3786-3792
Johnson, Caroline H; Athersuch, Toby J; Collman, Gwen W et al. (2017) Yale school of public health symposium on lifetime exposures and human health: the exposome; summary and future reflections. Hum Genomics 11:32
Wolff, Mary S; Buckley, Jessie P; Engel, Stephanie M et al. (2017) Emerging exposures of developmental toxicants. Curr Opin Pediatr 29:218-224
Uppal, Karan; Walker, Douglas I; Liu, Ken et al. (2016) Computational Metabolomics: A Framework for the Million Metabolome. Chem Res Toxicol 29:1956-1975
Jones, Dean P (2016) Hydrogen peroxide and central redox theory for aerobic life: A tribute to Helmut Sies: Scout, trailblazer, and redox pioneer. Arch Biochem Biophys 595:13-8

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