Abstract

1. Laboratory studies in rats. To use elastic scattering spectroscopy (ESS) to detect changes in tissue below the most superficial layer in the gastrointestinal tract. The ultimate purpose of this is to detect residual glands in the esophagus that may persist under regenerated squamous epithelium when PDT is used to treat Barrett's esophagus. 2. Laboratory studies in rats. To use elastic scattering spectroscopy (ESS) to assess the effect of PDT on the mucosa of the rat stomach. The purpose is to find out if ESS can determine whether glandular mucosal ablation is partial or complete and when is the best, and earliest, time after PDT to look. 3. Clinical. To refine ESS analysis for detection of dysplasia in Barrett's esophagus. This will involve a more sophisticated analysis of data we already have, gathering new data to improve the algorithms for spectral analysis and assessing these algorithms prospectively. The possibility of using ESS to detect aneuploidy will also be explored. 4. Clinical. To use OP and ESS to manage treatment and to monitor the results of PDT for dysplasia in Barrett's esophagus. This will include OP measurements of photosensitizer levels at the time of PDT to optimize light dosimetry and ESS measurements of tissue response at times from immediately after light delivery until healing is complete.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54CA104677-01
Application #
6825490
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2003-09-30
Project End
2008-08-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2003
Total Cost
Indirect Cost

  Institution

Name
Boston University
Department
Type
DUNS #
042250712
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Rodriguez-Diaz, Eladio; Atkinson, Christopher; Jepeal, Lisa I et al. (2014) Elastic scattering spectroscopy as an optical marker of inflammatory bowel disease activity and subtypes. Inflamm Bowel Dis 20:1029-36
Calabro, Katherine W; Bigio, Irving J (2014) Influence of the phase function in generalized diffuse reflectance models: review of current formalisms and novel observations. J Biomed Opt 19:75005
Ergin, Aysegul; Wang, Mei; Zhang, Jane Y et al. (2012) The feasibility of real-time in vivo optical detection of blood-brain barrier disruption with indocyanine green. J Neurooncol 106:551-60
Ergin, Aysegul; Wang, Mei; Zhang, Jane et al. (2012) Noninvasive in vivo optical assessment of blood brain barrier permeability and brain tissue drug deposition in rabbits. J Biomed Opt 17:057008
Bigio, Irving J (2012) Real-time pathology to guide breast surgery: seeing alone is not believing. Clin Cancer Res 18:6083-5
Rodriguez-Diaz, Eladio; Bigio, Irving J; Singh, Satish K (2011) INTEGRATED OPTICAL TOOLS FOR MINIMALLY INVASIVE DIAGNOSIS AND TREATMENT AT GASTROINTESTINAL ENDOSCOPY. Robot Comput Integr Manuf 27:249-256
Joshi, Shailendra; Ergin, Aysegul; Wang, Mei et al. (2011) Inconsistent blood brain barrier disruption by intraarterial mannitol in rabbits: implications for chemotherapy. J Neurooncol 104:11-9
Rodriguez-Diaz, Eladio; Castanon, David A; Singh, Satish K et al. (2011) Spectral classifier design with ensemble classifiers and misclassification-rejection: application to elastic-scattering spectroscopy for detection of colonic neoplasia. J Biomed Opt 16:067009
Joshi, Shailendra; Reif, Roberto; Wang, Mei et al. (2011) Intra-arterial mitoxantrone delivery in rabbits: an optical pharmacokinetic study. Neurosurgery 69:706-12; discussion 712
Keshtgar, M R S; Chicken, D W; Austwick, M R et al. (2010) Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer. Br J Surg 97:1232-9

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