The Genomics Core is responsible for the conduct of genome-wide expression analyses on blood T-cell, monocyte, and neutrophil samples obtained from trauma and burned patients. The Core will also conduct genome wide expression analyses on other non-blood tissues (primarily skin, muscle and fat) obtained from the burn patients. The activities of the Core are divided into two principal components: (1) routine analyses of samples generated from the PORC site initially using the macroscale techniques (see CSSP Core), and (2) methods development to conduct genome wide expression analysis on ever reducing quantities of RNA, derived from enriched cell populations obtained by'macroscale, and subsequently by microfluidics techniques. Data obtained from this Core generates meaningful data on the gene expression response to severe trauma and burn injury.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54GM062119-09
Application #
7924077
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
9
Fiscal Year
2009
Total Cost
$2,161,793
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
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