ABSTRAC- ADMINISTRATIVE CORE There is a need for well-coordinated infrastructure, multi-institutional and multidisciplinary collaborative networks that target specific populations and facilitate high-quality, cost-efficient and regulatory compliant research and health care strategies. The Hispanic Alliance for Clinical and Translational Research (the Alliance) will integrate clinical and translational research infrastructure and resources across a predominantly Hispanic U.S. jurisdiction to bridge the gaps between basic and clinical translational research, to address severe health conditions that disproportionately affect the medically underserved, and highly prevalent among Hispanic populations. The long-term goal of the Administrative Core of the Alliance is to provide a model for the optimal management and development clinical and translational research infrastructure in resource-limited settings that provide care to medically underserved populations. The specific objective of the Administrative Core will be to establish a leadership and management structure that will ensure that the Alliance KCA?s and milestones are met effectively and efficiently and when necessary realign the existing institutional and Alliance resources. This will be accomplished through three specific aims: 1) Provide an integrated organizational structure, leadership and advisory support system to effectively supervise, manage and monitor progress of all the Alliance key component activities/cores leading to achievement of the proposed milestones; 2) Develop and implement policies, procedures, and practices that ensure efficiency, sustainability, and scientific and fiscal flexibility to accommodate the changing needs and priorities of the Investigators, leading to new innovative and competitive areas of clinical and translational research; 3) Provide timely financial, dissemination, communication and evaluation functions that promote expansion of innovative clinical and translational research and services and long-term sustainability of the Alliance. The proposed administrative structure will bring together key leaders from the participating Institutions and external collaborators, further developing a pre-existing collaborative structure that has been successful in obtaining external funding and developing early-stage investigators. It will provide an efficient and integrated governance and administrative structure that will ensure the optimal and cost-effective utilization of resources. This will ultimately lead to successful advances in Clinical and Translational research in prevalent conditions in our population.
