The Administrative Core of the University of Rochester Medical Center (URMC) Wellstone MDCRCcoordinates and integrates the components & activities as well as the utilization of funds by the 2 scientificprojects, the Scientific Resources Core and the Training & Educational Core that comprise our WellstoneCenter. The Administrative Core gains vitality and effectiveness from the experience of its members, whohave performed these responsibilities over the past five years of our currently funded URMC WellstoneMDCRC. Dr. Richard Moxley, Director of our current Wellstone Center, and Dr. Charles Thornton, Co-Director, have worked together congenially and effectively and also have well established workingrelationships with other investigators involved in the scientific projects and cores proposed for our renewalfunded Wellstone Center. They have worked very closely with Dr. Rabi Tawil, who has directed the ImagingCore and one of the scientific projects in our currently funded Wellstone Center. Dr. Tawil will serve as co-investigatorin the Training and Educational Core of the renewal funded Center. Dr. Maurice Swanson isanother researcher with a well established working relationship with our proposed Center Director and Co-Director. Dr. Swanson has served as principal investigator of a scientific project in our currently fundedWellstone center and will serve as co-principal investigator in Project 2 of the renewal application. Mrs.Nancy Merriman, who is Administrator of our current Wellstone Center, will continue to serve asAdministrator of our renewal funded Center. The necessary communication network, knowledge of storageand confidentiality requirements, data tracking software, and computer facilities to operate a large-scale,multi-component, NIH funded, project are already in place. We have had a congenial and constructiveinteraction with the current members of our External Center Advisory Committee, and we will work with NIHprogram staff to identify researchers and lay members to serve on the Center Advisory Committee oncerenewal funding has occurred. The Administrative Core will bring together the robust assets that areavailable within the URMC, such as, the recently funded Clinical & Translational Sciences Institute and ourDepartmental resources, to facilitate the activities of our scientific projects and cores. We will have regularlyscheduled bi-weekly meetings, video-conferences, and bi-annual Advisory Committee meetings.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54NS048843-06
Application #
7535918
Study Section
Special Emphasis Panel (ZAR1-KM-J (M1))
Project Start
2008-09-30
Project End
2013-08-30
Budget Start
2008-09-30
Budget End
2009-08-30
Support Year
6
Fiscal Year
2008
Total Cost
$148,478
Indirect Cost
Name
University of Rochester
Department
Type
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Carrell, Samuel T; Tang, Zhenzhi; Mohr, Sabine et al. (2018) Detection of expanded RNA repeats using thermostable group II intron reverse transcriptase. Nucleic Acids Res 46:e1
Trembley, Michael A; Quijada, Pearl; Agullo-Pascual, Esperanza et al. (2018) Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy. Circulation 138:1864-1878
Auerbach, David S; Biton, Yitschak; Polonsky, Bronislava et al. (2018) Risk of cardiac events in Long QT syndrome patients when taking antiseizure medications. Transl Res 191:81-92.e7
Sznajder, ?ukasz J; Thomas, James D; Carrell, Ellie M et al. (2018) Intron retention induced by microsatellite expansions as a disease biomarker. Proc Natl Acad Sci U S A 115:4234-4239
Wood, Libby; Bassez, Guillaume; Bleyenheuft, Corinne et al. (2018) Eight years after an international workshop on myotonic dystrophy patient registries: case study of a global collaboration for a rare disease. Orphanet J Rare Dis 13:155
Jauvin, Dominic; Chrétien, Jessina; Pandey, Sanjay K et al. (2017) Targeting DMPK with Antisense Oligonucleotide Improves Muscle Strength in Myotonic Dystrophy Type 1 Mice. Mol Ther Nucleic Acids 7:465-474
Skov, Martin; Dirksen, Robert T (2017) Trojan triplets: RNA-based pathomechanisms for muscle dysfunction in Huntington's disease. J Gen Physiol 149:49-53
Pinto, Belinda S; Saxena, Tanvi; Oliveira, Ruan et al. (2017) Impeding Transcription of Expanded Microsatellite Repeats by Deactivated Cas9. Mol Cell 68:479-490.e5
Thornton, Charles A; Wang, Eric; Carrell, Ellie M (2017) Myotonic dystrophy: approach to therapy. Curr Opin Genet Dev 44:135-140
Gadalla, S M; Hilbert, J E; Martens, W B et al. (2017) Pigmentation phenotype, photosensitivity and skin neoplasms in patients with myotonic dystrophy. Eur J Neurol 24:713-718

Showing the most recent 10 out of 88 publications