The overall objective of this grant proposal is to establish a sustainable comprehensive partnership between Morehouse School of Medicine (MSM) and the University of Alabama Comprehensive Cancer Center in order to enhance the cancer research capabilities of each institution. It is the ultimate goal of the partnership to make a significant contribution to the elimination of the cancer incidence, morbidity and mortality gap seen between whites and African-Americans. The Partnership will be forged in the areas of cancer research, minority cancer research training and career development, and effective cancer control outreach to urban and rural African-American Communities. Collaborative cancer research projects in basic science, clinical, and cancer control will be established in the first year. In addition, a cancer outreach program to urban and rural African-Americans will be established in year one. By year two, a collaborative minority cancer research training and career development program will be instituted. Administration, planning and evaluation will be provided through a collaborative core composed of an Executive Committee, Scientific Review Committee, Program Development Committee, and Research Training and Career Development Committee. Satellite Biostatistical and Recruitment and Retention Shared Facility cores will be established in year one at MSM and become independent entities by year three, followed by other cores in years two -five. Finally, a formal alliance will be established between the institutions and a comprehensive partnership (U54) will be established within three years, if not sooner.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory Grants--Cooperative Agreements (U56)
Project #
5U56CA092078-05
Application #
6897029
Study Section
Special Emphasis Panel (ZCA1-SRRB-5 (J3))
Program Officer
Ogunbiyi, Peter
Project Start
2001-06-26
Project End
2007-04-30
Budget Start
2005-05-01
Budget End
2007-04-30
Support Year
5
Fiscal Year
2005
Total Cost
$435,361
Indirect Cost
Name
Morehouse School of Medicine
Department
Surgery
Type
Schools of Medicine
DUNS #
102005451
City
Atlanta
State
GA
Country
United States
Zip Code
30310
Johnson-Holiday, Crystal; Singh, Rajesh; Johnson, Erica et al. (2011) CCL25 mediates migration, invasion and matrix metalloproteinase expression by breast cancer cells in a CCR9-dependent fashion. Int J Oncol 38:1279-85
Singh, Shailesh; Singh, Rajesh; Singh, Udai P et al. (2009) Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines. Int J Cancer 125:2288-95
Singh, Shailesh; Singh, Rajesh; Sharma, Praveen K et al. (2009) Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion. Cancer Lett 283:29-35
Singh, Rajesh; Lillard Jr, James W (2009) Nanoparticle-based targeted drug delivery. Exp Mol Pathol 86:215-23
Singh, Shailesh; Singh, Udai P; Grizzle, William E et al. (2004) CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. Lab Invest 84:1666-76
Singh, Shailesh; Singh, Udai P; Stiles, Jonathan K et al. (2004) Expression and functional role of CCR9 in prostate cancer cell migration and invasion. Clin Cancer Res 10:8743-50