The mission of the Pediatric Heart Network (PHN) is to improve the health of children and adults with structural congenital heart defects, as well as children with acquired heart disease through multi-center clinical research. The Emory University Clinical Research Center combines the strengths and experience of Children's Healthcare of Atlanta, the Sibley Heart Center, the Emory Adult Congenital Heart Center, and Emory University School of Medicine with the goal of participating in a cooperative and interactive manner with the other Clinical Research Centers, the NHLBI, and the DCC to carry out the mission of the PHN.
The specific aims of the Emory Clinical Research Center are 1) to participate as a core site in multi-center studies evaluating medical, interventional and surgical therapies related to pediatric heart diseases and congenital heart diseases across the lifespan, 2) to provide a training platform for fellows, junior faculty, and nurses, 3) to support the development of novel techniques and methodologies, and 4) to promote dissemination of study results to improve the scientific basis for the care of affected individuals. To achieve these aims, the Emory site will propose and lead novel scientific trials and studies, take advantage of its database and registry resources to enhance clinical studies, utilize the unique expertise of key personnel with database and registry linkage and be an active contributor to PHN leadership via participation in PHN committees and writing groups. The experienced team of clinician researchers and dedicated research coordinators has a history of successful enrollment in difficult trials, timely data submission and active participation in data analysis and dissemination of results. The Emory Clinical Research Center brings special strengths to the PHN, including a high clinical volume of children with heart disease and adults with congenital heart disease drawn from demographically diverse population. Collectively, these contributions will ensure the success of the PHN. In order to improve the lives of children with heart disease and adults with congenital heart disease, it is necessary that cardiac programs work together to study the most important questions. The PHN provides the best opportunity to answer these questions and promote evidence based medicine for the care of affected individuals. The investigators of the Emory University Clinical Research Center have the experience, skills and desire to support the mission of the PHN and successfully carryout these vital clinical trials.

Public Health Relevance

The Emory University Clinical Research Center will carry out the mission of Pediatric Heart Network to improve health outcomes in patients with pediatric acquired and pediatric and adult congenital heart disease (CHD). This will be achieved by supporting research trials in these populations and communicating the findings to patients, families and care providers.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Research Cooperative Agreements - Single Project (UG1)
Project #
5UG1HL135682-04
Application #
9842321
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Pemberton, Victoria
Project Start
2017-01-01
Project End
2023-12-31
Budget Start
2020-01-01
Budget End
2020-12-31
Support Year
4
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Emory University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Newburger, Jane W; Sleeper, Lynn A; Gaynor, J William et al. (2018) Transplant-Free Survival and Interventions at 6 Years in the SVR Trial. Circulation 137:2246-2253
Mahle, William T; Hu, Chenwei; Trachtenberg, Felicia et al. (2018) Heart failure after the Norwood procedure: An analysis of the Single Ventricle Reconstruction Trial. J Heart Lung Transplant 37:879-885
Saarel, Elizabeth V; Granger, Suzanne; Kaltman, Jonathan R et al. (2018) Electrocardiograms in Healthy North American Children in the Digital Age. Circ Arrhythm Electrophysiol 11:e005808
Minich, L LuAnn; Pemberton, Victoria L; Shekerdemian, Lara S et al. (2018) The Pediatric Heart Network Scholar Award programme: a unique mentored award embedded within a multicentre network. Cardiol Young 28:854-861
Oster, Matthew E; Chen, Shan; Dagincourt, Nicholas et al. (2017) Development and impact of arrhythmias after the Norwood procedure: A report from the Pediatric Heart Network. J Thorac Cardiovasc Surg 153:638-645.e2
Nathan, Meena; Jacobs, Marshall L; Gaynor, J William et al. (2017) Completeness and Accuracy of Local Clinical Registry Data for Children Undergoing Heart Surgery. Ann Thorac Surg 103:629-636
Mahle, William T; Nicolson, Susan C; Hollenbeck-Pringle, Danielle et al. (2016) Utilizing a Collaborative Learning Model to Promote Early Extubation Following Infant Heart Surgery. Pediatr Crit Care Med 17:939-947