Contact PD/PI: Foroozesh, Maryam ABSTRACT (Overall) Xavier University of Louisiana is first nationally in the number of African American graduates who go on to earn doctoral degrees in the Life Sciences, and fifth in producing African American students who earn their PhDs in Science and Engineering. This success occurs in spite of the fact that Xavier is a relatively small, primarily undergraduate school and that the majority of its students face socioeconomic challenges. As medicine and pharmacy are familiar professions to Xavier students and their families, and since the University has a national reputation for producing health professionals, about 47% of Xavier's new freshmen enter a pre- medical curriculum and another 27% enter as pre-pharmacy students. However, of these students a large percentage does not enter professional or pharmacy programs for various reasons. Thus, there are a significant number of students at Xavier who are at risk of being left behind and who might choose careers in biomedical research with early awareness, career advising, and hands-on research opportunities. The national literature identifies unique barriers faced by underrepresented individuals entering into biomedical research careers, including the lack of: (1) early awareness and deepening exposure to the type of rewards associated with biomedical research careers, and the sense of accomplishment gained from success in early biomedical educational experiences; (2) supportive relationships, particularly those related to faculty advising and mentoring; (3) suitable educational infrastructure; and (4) active engagement in meaningful biomedical research experiences and the presence of faculty and institutional resources needed to do this and enter graduate programs successfully. The Building Integrated Pathways to Independence for Diverse Biomedical Researchers Program at Xavier University of Louisiana (Project Pathways) aims to transform Xavier's educational and support systems to better educate and engage students on the pathway to a biomedical research career, particularly those at high risk of not entering or of exiting this pathway. The second phase, Project Pathways II is responding to the findings of Project Pathways I by retaining, improving, or replacing initiatives as appropriate. Project Pathways II aims to identify the initiatives which are most impactful, cost-effective, sustainable, and transferable. The results of this Project Pathways II experiment will be widely disseminated to the greater academic community. ! Page 79 Project Summary/Abstract Contact PD/PI: Foroozesh, Maryam

Public Health Relevance

(Overall) There is a significant national shortage of African Americans and other individuals from underrepresented groups in the biomedical research workforce. Xavier University of Louisiana, a Historically Black and Catholic University, is nationally recognized for its Science, Technology, Engineering and Mathematics (STEM), pre- medical, and pharmacy programs, thus a significant proportion of students enter Xavier with medical (47%) or pharmacy (27%) career goals. Less than one third of these students each year go on to medical or other professional schools, leaving behind a large number of students in biomedical disciplines, who, with additional training and support, might choose careers in biomedical research; thus Xavier is positioned to play a unique and important role in not only producing scientists to meet the current and projected future demands for increased diversity in biomedical research fields, but also to share the results and assessment of various initiatives with the nation for use by other institutions. ! Page 80 Project Narrative

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1GM118967-07
Application #
9985876
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Brown, Anissa F
Project Start
2014-09-26
Project End
2024-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
7
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Xavier University of Louisiana
Department
Type
DUNS #
020857876
City
New Orleans
State
LA
Country
United States
Zip Code
70125
Komati, Rajesh; Mitchell, Carl A; LeBeaud, Anastasia et al. (2018) Tenacic Acids: A New Class of Tenacious Binders to Metal Oxide Surfaces. Chemistry 24:14824-14829
Toro, Tasha B; Edenfield, Samantha A; Hylton, Brandon J et al. (2018) Chelatable trace zinc causes low, irreproducible KDAC8 activity. Anal Biochem 540-541:9-14
Aqeel, Salem M; Huang, Zhongyuan; Walton, Jonathan et al. (2018) Polyvinylidene Fluoride (PVDF)/Polyacrylonitrile (PAN)/Carbon Nanotube Nanocomposites for Energy Storage and Conversion. Adv Compos Hybrid Mater 1:185-192
Zhang, Yan; Huang, Zhongyuan; Wang, Letao et al. (2018) Point-of-Care Determination of Acetaminophen Levels with Multi-Hydrogen Bond Manipulated Single-Molecule Recognition (eMuHSiR). Anal Chem 90:4733-4740
Hughes, Natalie; Nguyen, Nancy; Daley, Deanna-Kaye et al. (2018) Comparison of DNAzyme activity for the development of an immobilized heme sensor. MRS Adv 3:1491-1496
Xu, Liang; Wang, Zhe; Chen, Xu et al. (2018) Ultrathin layered double hydroxide nanosheets with Ni(III) active species obtained by exfoliation for highly efficient ethanol electrooxidation. Electrochim Acta 260:898-904
Toro, Tasha B; Painter, Richard G; Haynes, Rashad A et al. (2018) Purification of metal-dependent lysine deacetylases with consistently high activity. Protein Expr Purif 141:1-6
Sirohi, Sunil; Van Cleef, Arriel; Davis, Jon F (2017) Intermittent access to a nutritionally complete high-fat diet attenuates alcohol drinking in rats. Pharmacol Biochem Behav 153:105-115
Sridhar, Jayalakshmi; Goyal, Navneet; Liu, Jiawang et al. (2017) Review of Ligand Specificity Factors for CYP1A Subfamily Enzymes from Molecular Modeling Studies Reported to-Date. Molecules 22:
Gong, Jingjing; Muñoz, Amanda R; Pingali, Subramanya et al. (2017) Downregulation of STAT3/NF-?B potentiates gemcitabine activity in pancreatic cancer cells. Mol Carcinog 56:402-411

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