The goal of The Rockefeller University Center for Clinical and Translational Science is to improve human health by: 1. providing an infrastructure to conduct clinical investigation at the highest level, educational programs to train future generations of skilled and committed investigators, and novel methods of clinical investigation that can be shared with others, and 2. working closely with other CTSA institutions to set national standards so as to improve the conduct of clinical research. The 2006 Clinical and Translational Science Award transformed translational research at Rockefeller University and we propose to build on these accomplishments by: 1) enhancing our KL2 Master's degree and Certificate in Clinical and Translational Science educational programs; 2) creating a new educational program for our current K08 and K23 awardees to speed their transition to scientific independence; 3) expanding our bidirectional community engaged research with our partner institutions, integrating molecular mechanistic and population-based components, 4) completing the implementation of our integrated, customized information technology infrastructure to facilitate protocol development, review, and conduct; 5) implementing a novel real-time monitoring system to insure compliance with Good Clinical Practice; 6) enhancing our multi-disciplinary and multi-departmental Protocol Navigation program to speed protocol development, approval, and implementation, and extending it to bidirectional community engaged research; 7) expanding the application of novel nonparametric biostatistical methods to genomic and community-based investigation; 8) utilizing our new deep human phenotyping systems to aid scientific discovery and address important clinical needs; 9) utilizing a validated measure of research participants' perceptions to improve the conduct of clinical research; and 10) continuing to actively participate in the national CTSA consortium to advance the discipline of clinical and translational science for the benefit of human health.

Public Health Relevance

The Rockefeller University Center for Clinical and Translational Science is dedicated to improving human health by providing the resources and personnel to conduct the highest quality research to improve the prevention, diagnosis, and treatment of human disease. It also is producing novel methods to improve the scientific information obtained from clinical research studies and the way in which the research is performed.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR000043-10
Application #
8900379
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Merchant, Carol
Project Start
2006-09-30
Project End
2016-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
10
Fiscal Year
2015
Total Cost
$6,672,713
Indirect Cost
$2,436,127
Name
Rockefeller University
Department
Biology
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
Kong, Xiao-Fei; Martinez-Barricarte, Ruben; Kennedy, James et al. (2018) Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nat Immunol 19:973-985
Key, Kent D; Lewis, E Yvonne (2018) Sustainable community engagement in a constantly changing health system. Learn Health Syst 2:
Wittkowski, Knut M; Dadurian, Christina; Seybold, Martin P et al. (2018) Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer. PLoS One 13:e0199012
Alemán, José O; Bokulich, Nicholas A; Swann, Jonathan R et al. (2018) Fecal microbiota and bile acid interactions with systemic and adipose tissue metabolism in diet-induced weight loss of obese postmenopausal women. J Transl Med 16:244
Levin, Avi; Minis, Adi; Lalazar, Gadi et al. (2018) PSMD5 Inactivation Promotes 26S Proteasome Assembly during Colorectal Tumor Progression. Cancer Res 78:3458-3468
Esteve-Solé, Ana; Sologuren, Ithaisa; Martínez-Saavedra, María Teresa et al. (2018) Laboratory evaluation of the IFN-? circuit for the molecular diagnosis of Mendelian susceptibility to mycobacterial disease. Crit Rev Clin Lab Sci 55:184-204
Sundberg, Maria; Tochitsky, Ivan; Buchholz, David E et al. (2018) Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin. Mol Psychiatry 23:2167-2183
Vries, Minka J; van der Meijden, Paola E; Kuiper, Gerhardus J et al. (2018) Preoperative screening for bleeding disorders: A comprehensive laboratory assessment of clinical practice. Res Pract Thromb Haemost 2:767-777
Sajatovic, Martha; Tatsuoka, Curtis; Cassidy, Kristin A et al. (2018) A 6-Month, Prospective, Randomized Controlled Trial of Customized Adherence Enhancement Versus Bipolar-Specific Educational Control in Poorly Adherent Individuals With Bipolar Disorder. J Clin Psychiatry 79:
Allen, Baxter B; Forgacs, Peter B; Fakhar, Malik A et al. (2018) Association of Seizure Occurrence with Aneurysm Treatment Modality in Aneurysmal Subarachnoid Hemorrhage Patients. Neurocrit Care 29:62-68

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