Abstract

After a successful and highly productive first grant period, the Oregon Clinical and Translational Research Institute (OCTRI) is well positioned to have greater impact in the next grant period. OCTRI's goals are:
Specific Aim 1. Generate sustained OHSU and KPCHR research growth and productivity across the spectrum of translational science.
Specific Aim 2. Translate new biomedical knowledge into widespread advances in human health and healthcare reform.
Specific Aim 3. Create a regional consortium for clinical and translational research.
Specific Aim 4. Expand the impact of the strong OCTRI educational curriculum, develop an institution-wide, coordinated career development process that builds on the strengths of existing programs, and extend it throughout the region and nationally.
Specific Aim 5. Enhance key infrastructure programs to support local and regional clinical and translational research. These plans will build on major progress during the first grant period to further expand clinical and translational research, career development and benefits to human health. OCTRI will utilize a series of innovative partnerships to leverage CTSA support, expand its extensive collaborations with communities, and take advantage of a regional consortium of academic institutions working together to enhance translation. As a member of the CTSA Consortium, OCTRI will contribute unique expertise and resources to the combined effort to solve biomedical problems. Oregon Health and Science University and its partner institution Kaiser Permanente Center for Health Research have committed strong leadership support and substantial institutional commitment to OCTRI's continued mission.

Public Health Relevance

OCTRI will have a major influence on clinical and translational research at OHSU and KPCHR, and will increase their contributions to biomedical discovery. As the only academic medical center in Oregon, OHSU has a unique opportunity to catalyze translational research growth on a regional scale. Via its participation in the CTSA Consortium, OCTRI will advance national research productivity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
8UL1TR000128-07
Application #
8277875
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Sufian, Meryl
Project Start
2006-09-30
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
7
Fiscal Year
2012
Total Cost
$7,199,169
Indirect Cost
$2,321,310

  Institution

Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Harvey, Nicholas C; Odén, Anders; Orwoll, Eric et al. (2018) Measures of Physical Performance and Muscle Strength as Predictors of Fracture Risk Independent of FRAX, Falls, and aBMD: A Meta-Analysis of the Osteoporotic Fractures in Men (MrOS) Study. J Bone Miner Res 33:2150-2157
Nowak, Kristen L; Yaffe, Kristine; Orwoll, Eric S et al. (2018) Serum Sodium and Cognition in Older Community-Dwelling Men. Clin J Am Soc Nephrol 13:366-374
Eurelings, Lisa Sm; van Dalen, Jan Willem; Ter Riet, Gerben et al. (2018) Apathy and depressive symptoms in older people and incident myocardial infarction, stroke, and mortality: a systematic review and meta-analysis of individual participant data. Clin Epidemiol 10:363-379
Wright, N C; Hooker, E R; Nielson, C M et al. (2018) The epidemiology of wrist fractures in older men: the Osteoporotic Fractures in Men (MrOS) study. Osteoporos Int 29:859-870
Bonham, Luke W; Evans, Daniel S; Liu, Yongmei et al. (2018) Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes. Am J Alzheimers Dis Other Demen 33:153-165
Harvey, Nicholas C; Odén, Anders; Orwoll, Eric et al. (2018) Falls Predict Fractures Independently of FRAX Probability: A Meta-Analysis of the Osteoporotic Fractures in Men (MrOS) Study. J Bone Miner Res 33:510-516
Chen, Han; Cade, Brian E; Gleason, Kevin J et al. (2018) Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men. Am J Respir Cell Mol Biol 58:391-401
Gera, Geetanjali; Chesnutt, Jim; Mancini, Martina et al. (2018) Inertial Sensor-Based Assessment of Central Sensory Integration for Balance After Mild Traumatic Brain Injury. Mil Med 183:327-332
Leng, Yue; Goldman, Samuel M; Cawthon, Peggy M et al. (2018) Excessive daytime sleepiness, objective napping and 11-year risk of Parkinson's disease in older men. Int J Epidemiol 47:1679-1686
Nagarkatti-Gude, Nisha; Li, Yan; Huang, David et al. (2018) Optical coherence tomography angiography of a pigmented Fuchs' adenoma (age-related hyperplasia of the nonpigmented ciliary body epithelium) masquerading as a ciliary body melanoma. Am J Ophthalmol Case Rep 9:72-74

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