The overall goal of the Mayo Clinic CTSA is to continue to build a broad-based and integrated home for clinical and translational science (CTS) at Mayo Clinic that will ultimately improve human health. In this context, we seek to make the Mayo CTSA and the resources it leverages both an engine of efficiency for clinical and translational research and at the same time a driver of innovation. We also seek to integrate our local activities with consortium wide efforts directed at coordination and alignment. To achieve our goal we have six overarching specific aims for this renewal:
Aim 1 - Train and maintain an outstanding multidisciplinary clinical and translational sciences workforce. This workforce includes teams of both investigators and support staff.
Aim 2 - Eliminate barriers to the work of translation. This will be accomplished through a) continued efforts at regulatory and compliance streamlining, b) provision of outstanding design, biostatistics, and ethics support for investigators, and c) further integration of support services.
Aim 3 - Collaborate with providers and communities to improve health care delivery and community health. This includes substantial commitments to practice-based research, community- engaged research and translating comparative effectiveness research into clinical practice.
Aim 4 - Deploy advanced facilities and other core resources to increase the value of clinical research. With value defined in this context as the quotient of quality and cost, the goal is to increase quality, decrease costs, and provide resources to the full spectrum of clinical and translational investigation.
Aim 5 - Stimulate novel research directions and methodologies by targeted support of innovative pilot and feasibility studies and fostering the development of novel methodologies.
Aim 6 - Employ informatics to integrate and facilitate clinical and translational investigation. This encompasses a broad view of informatics including: a) developing a standardized electronic data capture and analysis tools for CTS, b) robust consultation and tools for medical informatics that leverage Mayo's commitments to electronic clinical systems, and c) bioinformatics services and capabilities that will help facilitate the application of the """"""""new biology"""""""" to clinical and translational investigation. This vision is entirely consistent with the stated mission of Mayo Clinic: """"""""To provide the best care to every patient every day through integrated clinical practice, education, and research.""""""""

Public Health Relevance

Mayo Clinic Center for Translational Science Activities will bring together all the resources of the five schools within the Mayo Clinic College of Medicine and more than 100 years of scientific and medical research expertise, to discover innovative new methods that will speed the translation of research results into therapies, tools, and patient care practices that impact both our local and national communities by improving their health.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR000135-08
Application #
8499944
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Rosenblum, Daniel
Project Start
2006-09-30
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
8
Fiscal Year
2013
Total Cost
$9,738,098
Indirect Cost
$1,577,615
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Greenberg-Worisek, Alexandra J; Campbell, Katherine A; Klee, Eric W et al. (2018) Case-Based Learning in Translational Biomedical Research Education Provides More Realistic and Adaptive Skills for Early-Career Scientists Than Didactic Sessions. Acad Med :
Wang, Runsheng; Crowson, Cynthia S; Wright, Kerry et al. (2018) Clinical Evolution in Patients With New-Onset Inflammatory Back Pain: A Population-Based Cohort Study. Arthritis Rheumatol 70:1049-1055
McCoy, Rozalina G; Peterson, Stephanie M; Borkenhagen, Lynn S et al. (2018) Which Readmissions May Be Preventable? Lessons Learned From a Posthospitalization Care Transitions Program for High-risk Elders. Med Care 56:693-700
Paradise, Christopher R; Galeano-Garces, Catalina; Galeano-Garces, Daniela et al. (2018) Molecular characterization of physis tissue by RNA sequencing. Gene 668:87-96
Ketha, Hemamalini; Thacher, Tom D; Oberhelman, Sara S et al. (2018) Comparison of the effect of daily versus bolus dose maternal vitamin D3 supplementation on the 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 ratio. Bone 110:321-325
Hruska, Carrie B; Geske, Jennifer R; Swanson, Tiffinee N et al. (2018) Quantitative background parenchymal uptake on molecular breast imaging and breast cancer risk: a case-control study. Breast Cancer Res 20:46
Zleik, Nour; Elfishawi, Mohanad M; Kvrgic, Zoran et al. (2018) Hospitalization Increases the Risk of Acute Arthritic Flares in Gout: A Population-based Study over 2 Decades. J Rheumatol 45:1188-1191
Covassin, Naima; Sert-Kuniyoshi, Fatima H; Singh, Prachi et al. (2018) Experimental Weight Gain Increases Ambulatory Blood Pressure in Healthy Subjects: Implications of Visceral Fat Accumulation. Mayo Clin Proc 93:618-626
Li, Ying; Chaiteerakij, Roongruedee; Kwon, Jung Hyun et al. (2018) A model predicting short-term mortality in patients with advanced liver cirrhosis and concomitant infection. Medicine (Baltimore) 97:e12758
Kleinstern, Geffen; Camp, Nicola J; Goldin, Lynn R et al. (2018) Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis. Blood 131:2541-2551

Showing the most recent 10 out of 1374 publications