The Yale Center for Clinical Investigation (YCCI) was created to provide a """"""""home"""""""" for training the next generation of clinical investigators. Key programmatic goals are to 1) attract highly talented students and junior faculty across medicine, nursing, public health, biological sciences and biomedical engineering;and train them in the use of state-of-the-art research tools;give them the skills to work within complex research teams;and support their professional development;and 2) foster the translation of disease-related discoveries from the laboratory into the clinic and then the community by: stimulating the creation of interdisciplinary teams;making available state-of-the-art core facilities and expanded biostatistical and bioinformatics resources;establishing organizational and regulatory infrastructure for clinical studies;and forging new partnerships that will integrate community leaders, physicians, and health centers and encourage participation in research. Participating institutions include the Schools of Medicine, Nursing, and Public Health, the department of Biomedical Engineering and the Graduate Programs in Biological and Biomedical Sciences. The Junior Faculty Scholars award program and the Investigative Medicine program (IMP) are central to YCCI's education and training efforts. IMP is a unique doctoral program that offers Ph.D. degrees in Health Sciences Research to highly qualified M.D. fellows embarking on careers in translational or clinical research and the junior faculty scholars program is a career development program. YCCI has also created a Society of Mentors who participates actively in the training and nurturing of the YCCI Scholars. Pilot and feasibility (P&F) grants will be awarded for: 1) interdisciplinary translational team research;2) development of novel methodologies;3) Use of Core (incl imaging) technologies;and 4) community-based research. YCCI will cluster research cores around common themes, including: imaging;genomics and proteomics;cell and tissue based tech;Integrated metabolics;cognition and biobehavior;and animal models. The Office of Research Services will provide robust facilities and resources for regulatory, biostatistical, bioinformatics, recruitment and other support services. YCCI will have an office to coordinate the University's efforts to address health issues facing our community and our national community.

Public Health Relevance

This research has direct relevance to public health in that its goals are to facilitate clinical research, including by training the next generation of clinical researchers that will lead to better treatments for human disease and better health outcomes.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR000142-08
Application #
8512834
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Merchant, Carol
Project Start
2006-09-30
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
8
Fiscal Year
2013
Total Cost
$7,386,771
Indirect Cost
$2,227,298
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Garcia-Martinez, Irma; Weiss, Theresa R; Yousaf, Muhammad N et al. (2018) A leukocyte activation test identifies food items which induce release of DNA by innate immune peripheral blood leucocytes. Nutr Metab (Lond) 15:26
Preller, Katrin H; Burt, Joshua B; Ji, Jie Lisa et al. (2018) Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor. Elife 7:
Gruenbaum, Shaun E; Dhaher, Roni; Rapuano, Amedeo et al. (2018) Effects of Branched-Chain Amino Acid Supplementation on Spontaneous Seizures and Neuronal Viability in a Model of Mesial Temporal Lobe Epilepsy. J Neurosurg Anesthesiol :
Huber, Markus; Wolf, Robert Christian; Lepping, Peter et al. (2018) Regional gray matter volume and structural network strength in somatic vs. non-somatic delusional disorders. Prog Neuropsychopharmacol Biol Psychiatry 82:115-122
Benjamin, Christopher F A; Li, Alexa X; Blumenfeld, Hal et al. (2018) Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning. Hum Brain Mapp 39:2777-2785
Sterzer, Philipp; Adams, Rick A; Fletcher, Paul et al. (2018) The Predictive Coding Account of Psychosis. Biol Psychiatry 84:634-643
Trombetti, Andrea; Hars, Mélany; Hsu, Fang-Chi et al. (2018) Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial. Ann Intern Med 168:309-316
Eid, Tore; Lee, Tih-Shih W; Patrylo, Peter et al. (2018) Astrocytes and Glutamine Synthetase in Epileptogenesis. J Neurosci Res :
Oliveira, Carlos R; Rock, Robert M; Shapiro, Eugene D et al. (2018) Missed opportunities for HPV immunization among young adult women. Am J Obstet Gynecol 218:326.e1-326.e7
Sherr, Jennifer L (2018) Closing the Loop on Managing Youth With Type 1 Diabetes: Children Are Not Just Small Adults. Diabetes Care 41:1572-1578

Showing the most recent 10 out of 790 publications