This CTSA renewal application is built on the research infrastructure, training programs, and partnerships we established in the first grant period, through creation ofthe Institute for Clinical and Translational Sciences (ICTS), which brought about significant cultural and organizational changes at Washington University in St. Louis and unprecedented collaboration between its partner institutions, including BJC HealthCare, Barnes-Jewish Hospital, St. Louis Children's Hospital, Saint Louis University, University of Missouri - St. Louis, Southern Illinois University Edwardsville, Goldfarb School of Nursing at Barnes-Jewish College, and the St. Louis College of Pharmacy. The overall goal of this application is to promote the translation of scientific discoveries into improvements in human health.
Our specific aims will transform our research support infrastructure to foster multidisciplinary clinical and translational research, expand and enhance clinical and translational research education programs, and promote communication and collaborative research with regional and national partners. New initiatives include 3 new cross-cutting scientific themes where the resources of our ICTS are most likely to result in high-impact clinical research and its subsequent translation into clinical practice: translating the findings of genetic/genomic research into clinical research and practice, accelerating the development and evaluation of new therapeutics, and conducting comparative effectiveness and dissemination and implementation research to improve the transfer of research into practice. To ensure the continued success of the ICTS, WU has made significant commitments of space and financial support. Barnes-Jewish Hospital and St Louis Children's Hospital, our academic hospital partners, and BJC HealthCare, our affiliated health system, have also made substantial comhnitments to suppport the clinical and translational research activities ofthe ICTS. This institutionalsupport, combined with the programs and collaborations we have started in the past four years, ensure that the ICTS will continue to make outstanding contributions in clinical and translational science.

Public Health Relevance

The overall goal of this grant is to promote the translation of scientific discoveries into improvements in human health. Our proposal will improve clinical research infrastructure, services, and training programs in order to speed the translation of new discoveries from the lab into humans, and to help implement the best medical evidence into clinical practice.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR000448-07
Application #
8499472
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Sawczuk, Andrea
Project Start
2007-09-17
Project End
2017-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
7
Fiscal Year
2013
Total Cost
$7,710,832
Indirect Cost
$2,309,159
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Poppler, Louis H; Parikh, Rajiv P; Bichanich, Miles J et al. (2018) Surgical interventions for the treatment of painful neuroma: a comparative meta-analysis. Pain 159:214-223
Lee, Seonjoo; Zimmerman, Molly E; Narkhede, Atul et al. (2018) White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease. PLoS One 13:e0195838
Haller, Gabe; Zabriskie, Hannah; Spehar, Shelby et al. (2018) Lack of joint hypermobility increases the risk of surgery in adolescent idiopathic scoliosis. J Pediatr Orthop B 27:152-158
Potter, Robert F; D'Souza, Alaric W; Wallace, Meghan A et al. (2018) Superficieibacter electus gen. nov., sp. nov., an Extended-Spectrum ?-Lactamase Possessing Member of the Enterobacteriaceae Family, Isolated From Intensive Care Unit Surfaces. Front Microbiol 9:1629
Panupattanapong, Sirada; Stwalley, Dustin L; White, Andrew J et al. (2018) Epidemiology and Outcomes of Granulomatosis With Polyangiitis in Pediatric and Working-Age Adult Populations In the United States: Analysis of a Large National Claims Database. Arthritis Rheumatol 70:2067-2076
Harris-Hayes, Marcie; Steger-May, Karen; van Dillen, Linda R et al. (2018) Reduced Hip Adduction Is Associated With Improved Function After Movement-Pattern Training in Young People With Chronic Hip Joint Pain. J Orthop Sports Phys Ther 48:316-324
Mostafa, Heba H; Thompson, Thornton W; Konen, Adam J et al. (2018) Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced Reactivation. J Virol 92:
Muenks, Carol E; Sewell, Whitney C; Hogan, Patrick G et al. (2018) Methicillin-Resistant Staphylococcus aureus: The Effects Are More Than Skin Deep. J Pediatr 199:158-165
Cardet, Juan Carlos; Louisias, Margee; King, Tonya S et al. (2018) Income is an independent risk factor for worse asthma outcomes. J Allergy Clin Immunol 141:754-760.e3
Garbutt, Jane M; Dodd, Sherry; Walling, Emily et al. (2018) Barriers and facilitators to HPV vaccination in primary care practices: a mixed methods study using the Consolidated Framework for Implementation Research. BMC Fam Pract 19:53

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