The Johns Hopkins Institute for Clinical and Translational Research (ICTR) is dedicated to creating a new model for conducting clinical and translational research throughout the Johns Hopkins University, by addressing critical obstacles that impede the progress of basic science discoveries to the clinic, clinical discoveries into the community and results back to the research community. To propel additional high impact and efficient translational research, the ICTR will create Translational Research Communities and The Studio. Three Translational Research Communities will be organized around: 1) drugs, biologies, vaccines and devices; 2) biomarkers and diagnostic tests and 3) behavioral, social and systems interventions. These communities of researchers will help prioritize important clinical problems, develop new technologies and methodologies, support junior investigators, work with translational partners outside of Johns Hopkins, and promote efficient research. The Studio is both a place and a process by which research teams can present problems and get integrated, efficient, multidisciplinary consultations from multiple experts. With the emergence of complex big data originating from genomic as well as electronic health records, the ICTR has expanded the Quantitative Methodologies and Informatics Cores to create an integrated platform of data services. These new programs will assist our multiple research teams across the University to access a large array of services provided in five ICTR Cores: Translational Science, Human Subjects Research, Quantitative Methodology, Informatics and Research Participant and Community Partnership. Translational research is changing with more ambitious goals and access to more tools. Johns Hopkins University will continue to provide rigorous, comprehensive training to learners that range from graduate students, fellows, and junior faculty to practicing physicians so they are able to lead and work effectively in translational research teams. Through these innovative and comprehensive programs, the ICTR wants to lead Johns Hopkins University to be an exceptional engine of discovery and innovation.

Public Health Relevance

By identifying and overcoming barriers in the translational pathway, increasing scientific collaboration, providing consultative services, clinical infrastructure, and technology cores that bridge the gap between the laboratory and the clinic, the ICTR helps to speed the pace of scientific discovery, and bring effective therapies to the public, and improve the health of Americans.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR001079-05
Application #
9310274
Study Section
Special Emphasis Panel (ZAI1-PTM-C (S2))
Program Officer
Brazhnik, Olga
Project Start
2013-09-26
Project End
2018-04-30
Budget Start
2017-05-01
Budget End
2018-04-30
Support Year
5
Fiscal Year
2017
Total Cost
$11,904,598
Indirect Cost
$2,128,639
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Bergbower, Emily; Boinot, Clement; Sabirzhanova, Inna et al. (2018) The CFTR-Associated Ligand Arrests the Trafficking of the Mutant ?F508 CFTR Channel in the ER Contributing to Cystic Fibrosis. Cell Physiol Biochem 45:639-655
Mellor-Crummey, Lauren E; Lake, Jordan E; Wilhalme, Holly et al. (2018) A Comparison of the Liver Fat Score and CT Liver-to-Spleen Ratio as Predictors of Fatty Liver Disease by HIV Serostatus. J Clin Gastroenterol Hepatol 2:
Austin, Thomas R; Wiggins, Kerri L; Blackshear, Chad et al. (2018) Atrial fibrillation in an African-American cohort: The Jackson Heart Study. Clin Cardiol 41:1049-1054
Stephens, Jaclyn A; Salorio, Cynthia F; Barber, Anita D et al. (2018) Preliminary findings of altered functional connectivity of the default mode network linked to functional outcomes one year after pediatric traumatic brain injury. Dev Neurorehabil 21:423-430
Riggs, Kevin R; Bass, Eric B; Segal, Jodi B (2018) Role of Patient- and Surgery-Specific Risk in Receipt of Outpatient Preoperative Testing. Perioper Care Oper Room Manag 10:18-26
Haljas, Kadri; Amare, Azmeraw T; Alizadeh, Behrooz Z et al. (2018) Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits. Psychosom Med 80:242-251
Dolce, Alison; Santos, Polan; Chen, Weiran et al. (2018) Different ketogenesis strategies lead to disparate seizure outcomes. Epilepsy Res 143:90-97
Budoff, Matthew J; Young, Rebekah; Burke, Gregory et al. (2018) Ten-year association of coronary artery calcium with atherosclerotic cardiovascular disease (ASCVD) events: the multi-ethnic study of atherosclerosis (MESA). Eur Heart J 39:2401-2408
Kelso-Chichetto, N E; Okafor, C N; Cook, R L et al. (2018) Association Between Depressive Symptom Patterns and Clinical Profiles Among Persons Living with HIV. AIDS Behav 22:1411-1422
Ying, Wendy; Zhao, Di; Ouyang, Pamela et al. (2018) Sex Hormones and Change in N-Terminal Pro-B-Type Natriuretic Peptide Levels: The Multi-Ethnic Study of Atherosclerosis. J Clin Endocrinol Metab 103:4304-4314

Showing the most recent 10 out of 1103 publications