This application focuses on ethnoracial health disparities as a barrier for participation in Down syndrome research. A disproportionately higher rate of African American with Down syndrome die as young adults when compared to Whites with Down syndrome and little is known related to differences in risk for a variety of age-related diseases in Down syndrome, including Alzheimer?s disease.
The first aim of the supplement is to develop culturally and linguistically appropriate educational and recruitment materials related to research participation in Down Syndrome for African Americans with Down syndrome and their families and caregivers. The application will develop recruitment materials, evaluate community members acceptance of these materials, and refine these materials based on community feedback. These materials will target adults with Down syndrome and Alzheimer?s disease.
The second aim i s to increase recruitment of individuals with Down syndrome into related studies in the clinical trial portal Pitt+Me (https://pittplusme.org/) from diverse populations. Success will be measured by enrollment of African Americans into Down syndrome-related studies into this portal.

Public Health Relevance

The University of Pittsburgh Clinical and Translational Science Institute (CTSI) is the academic home for clinical and translational science in western Pennsylvania. Over the next 5 years, we will apply our infrastructure, training programs, best practices, and novel approaches to support translational science and scientists and to advance each of the national CTSA goals.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1TR001857-04S1
Application #
9988649
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Brazhnik, Olga
Project Start
2016-07-12
Project End
2021-05-31
Budget Start
2019-09-11
Budget End
2020-05-31
Support Year
4
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15260
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