Abstract

TheUniversityofKentucky(UK)CenterforClinicalandTranslationalScience(CCTS)hascreatedan integratedhomeforclinicalandtranslationalresearchtopromotescientificprogressanddiscoveriesatevery phaseofthetranslationalcontinuum.TheCCTShasfundamentallytransformedtheresearchenvironmentnot onlyatUKbutthroughoutCentralAppalachiathroughthedevelopmentofastrongresearchnetwork,the AppalachianTranslationalResearchNetwork(ATRN),withintegratedresearchpartnershipsincludingother CTSAhubs.Whencombinedwithanin-depthunderstandingoftheuniqueandserioushealthchallenges facedbyCentralAppalachianresidents,theUKCCTSispositionedtoleadlocal,regionalandnational researcheffortsthatfocusonthesignificanthealthdisparitiesinthispopulation.Ouroverarchinggoalasa CTSAhubistocontinuetochampioninnovationinthefullspectrumofclinicalandtranslationalresearchwhile educatingtheworkforceofthefuture,engagingourcommunitiesinbiomedicalscienceandworkingwiththe nationalnetworktoadvancecohesivemulti-centerclinicaltrials,whichwillultimatelyelevatethehealthand qualityoflifeofthepopulaceofCentralAppalachia.Specifically,theUKCCTSwill:1)Leadinstitutional innovationinthedeliveryofefficient,effectiveclinicalandtranslationalresearch.2)Developadiverse workforceacrossmultipledisciplinesthatadvancestranslationalresearchandexcelsinteam-basedscience. 3)MeettheuniqueneedsofCentralAppalachianresidentsbyextensivelyengagingandcollaboratingwithour regional,ruralandcommunity-basedpartners.4)Catalyzeinnovativeresearch,includingnoveldrug developmentandinformaticsmethodologies,withparticularfocusonbringinginnovationtospecialpopulations andacrossthelifespan.5)Createanefficientclinicaltrialsnetwork,centeredatUK,andextendingintoour partnerhealthcaresystemsthatwillbeanessentialandleadingcomponentoftheCTSAconsortium,involving participantsthroughoutafourstateregionofruralCentralAppalachia.TheUKCCTSbenefitsfroma collaborativeenvironmentfoundononlyafewuniversitycampuses.UKhas16colleges,with11involvedin theUKCCTS(includingsixbiomedicalcolleges)ononecentralcampus.Thisphysicalproximityofour academicandhealthcarecommunities,alongwithacultureofcollaboration,createsacloselyknitunified academiccommunityandpositionstheUKCCTStodemonstratetheimpactofcollaborativetranslational researchandleadershipinteamscience.Oureffortshavealreadybeensuccessfulattransformingtheculture oftheUKacademicmedicalcentertoonethatmorekeenlyappreciatesscholarship,innovationand translationalscience.Wenowplantobuildonthesestrengthstoadvancetranslationalsciencetothenext level,withfurtherdevelopmentofourclinicaltrialnetworks,developmentofnovelinformaticsprograms,and continueddevelopmentoftheworkforcethroughouttheregion.Theseeffortswillbenefitthemedically underservedresidentsofCentralAppalachiaandwillsignificantlycontributetothenationalCTSAprogram. 1 Project Summary/Abstract Page 287 Contact PD/PI: Kern, Philip A

Public Health Relevance

The University of Kentucky (UK) Center for Clinical and Translational Science (CCTS) is strategically positioned in Central Appalachia to catalyze efforts to connect the populace of this medically underserved region, with significant health disparities, to the national CTSA network. The UK CCTS is recognized locally and regionally for affecting change and building robust partnerships across the CTSA network, in Central Appalachia and at UK, creating an efficient platform for clinical and translational research and training, all to improve quality of care, health, and well-being for the rural populations of this region. 1 Project Narrative Page 288

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR001998-04
Application #
9722327
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Brazhnik, Olga
Project Start
2016-08-15
Project End
2020-05-31
Budget Start
2019-06-01
Budget End
2020-05-31
Support Year
4
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of Kentucky
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40526

  Publications

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Ding, Kai; Zhou, Ziyuan; Zhou, Shuo et al. (2018) Design, synthesis, and discovery of 5-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones and related derivatives as novel inhibitors of mPGES-1. Bioorg Med Chem Lett 28:858-862
Hampton, Kaia K; Anderson, Katie; Frazier, Hilaree et al. (2018) Insulin Receptor Plasma Membrane Levels Increased by the Progesterone Receptor Membrane Component 1. Mol Pharmacol 94:665-673
de Medeiros, Aliandra G; Savi, Daiani C; Mitra, Prithiba et al. (2018) Bioprospecting of Diaporthe terebinthifolii LGMF907 for antimicrobial compounds. Folia Microbiol (Praha) 63:499-505
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Becker, Richard C; Sexton, Travis; Smyth, Susan S (2018) Translational Implications of Platelets as Vascular First Responders. Circ Res 122:506-522
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Gedaly, Roberto; De Stefano, Felice; Turcios, Lilia et al. (2018) mTOR Inhibitor Everolimus in Regulatory T cell Expansion for Clinical Application in Transplantation. Transplantation :

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