Contact PD/PI: Blazar, Bruce A. Overall: Abstract. The University of Minnesota's Clinical and Translational Science Institute's (UMN CTSI) vision is a world where impactful discoveries leading to the betterment of human health occur by bringing together Academic Health Center (AHC) research with community outreach and industry partnership. Our mission is to create a nationally-recognized, shareable model of complex translational team science driven and enabled by integration and alignment of clinical and translational science (CTS) research with education, data access, community needs, and industry efforts. In the past 6 years, CTSI 1) Developed comprehensive programs for workforce training and fostering career development for the next generation of CTS research investigators; 2) Created Community Engagement to Advance Research and Community Health (CEARCH) to support stakeholder community contributions to CTS research and to tackle health outcome disparity challenges in Somali, Latino, Native American, Hmong, and other populations; 3) Leveraged UMN research strengths and MN's vibrant biomedical industry to advance multiple projects along the commercialization pathway; and 4) Expanded its patient base from the UMN tertiary care adult and pediatric hospitals to hub partners consisting of a VA hospital, a community-based 7-hospital system, and a safety-net county hospital with 65% racial/ethnic minorities linked with i2b2/SHRINE for cohort identification. CTSI formed an unprecedented partnership with Mayo CTSA to provide statewide coverage in CTS research and education and is a founding member of the Midwest Area Research Consortium for Health, the Accrual to Clinical Trials federated cohort discovery consortium, and PCORnet Greater Plains Collaborative. To accelerate and improve CTS research and education and make lasting impacts on healthcare outcomes, we will pursue the following aims: 1. Train an outstanding multidisciplinary, diverse workforce across the CTS research spectrum skilled in and rewarded for team science using existing and new educational offerings; 2. Streamline methods and processes to increase local and national CTSI hub research capacity in a new Clinics and Surgery Center learning health system with CTSI-led research process design, CTSI's new StudyFinder tool, user-friendly IRB-approved consent form for clinical and laboratory research, bioinfor- matics tools, biospecimen collection, and a transformative Clinical Research Support Center for one-stop, single location, parallel processing of needed approvals; 3. Engage communities and stakeholders through CEARCH to improve translation and healthcare delivery across the lifespan and to a diverse population; and 4. Add unique contributions to the CTSA network by the Office of Discovery and Translation , Pediatric Device Innovation Consortium, and high and ultrahigh magnetic resonance imaging and spectroscopy applications and training. Impact. Connected to and driven by its vision and mission, CTSI will provide infrastructure and services for conducting innovative, high-impact and efficient, high-quality CTS research. Project Summary/Abstract Page 391 Contact PD/PI: Blazar, Bruce

Public Health Relevance

The University of Minnesota's Clinical and Translational Science Institute (UMN CTSI) aims to create a nationally-recognized, shareable model of complex clinical and translational team science (CTS) driven by integration and alignment of CTS research with education, data access, and community and industry partnership. In pursuit of this aim and widespread health improvement, the CTSI will develop new CTS technologies and training programs, ensure CTS research of the highest quality and ethical standards, prepare investigators to be successful as the next generation of national CTS leaders, and create opportunities for CTS researchers to directly involve community members in all stages of their research. The CTSI will also focus on reducing health disparities by bringing clinical research to local underserved populations, advancing research to successful commercialization, and sharing unique UMN assets with the national consortium. Project Narrative Page 392

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR002494-02
Application #
9676386
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Zhang, Xinzhi
Project Start
2018-03-30
Project End
2023-02-28
Budget Start
2019-03-01
Budget End
2020-02-29
Support Year
2
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Pediatrics
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Bellamri, Medjda; Xiao, Shun; Murugan, Paari et al. (2018) Metabolic Activation of the Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine in Human Prostate. Toxicol Sci 163:543-556
Grzywacz, Bartosz; Moench, Laura; McKenna Jr, David et al. (2018) Natural Killer Cell Homing and Persistence in the Bone Marrow After Adoptive Immunotherapy Correlates With Better Leukemia Control. J Immunother :
Chen, Mo; Lixandrão, Maíra C; Prudente, Cecília N et al. (2018) Short Interval Intracortical Inhibition Responses to Low-Frequency Repetitive Transcranial Magnetic Stimulation Under Multiple Interstimulus Intervals and Conditioning Intensities. Neuromodulation 21:368-375
Hegerova, Livia; Bachan, Adam; Cao, Qing et al. (2018) Catheter-Related Thrombosis in Patients with Lymphoma or Myeloma Undergoing Autologous Stem Cell Transplantation. Biol Blood Marrow Transplant 24:e20-e25
Guo, Jingshu; Villalta, Peter W; Weight, Christopher J et al. (2018) Targeted and Untargeted Detection of DNA Adducts of Aromatic Amine Carcinogens in Human Bladder by Ultra-Performance Liquid Chromatography-High-Resolution Mass Spectrometry. Chem Res Toxicol :
Larson, Nicole; Wang, Qi; Grannon, Katherine et al. (2018) A Low-Cost, Grab-and-Go Breakfast Intervention for Rural High School Students: Changes in School Breakfast Program Participation Among At-Risk Students in Minnesota. J Nutr Educ Behav 50:125-132.e1
Zhu, Huichen; Li, Gen; Lock, Eric F (2018) Generalized integrative principal component analysis for multi-type data with block-wise missing structure. Biostatistics :
Hall, Kelly E; Boller, Manuel; Hoffberg, Jayme et al. (2018) ACVECC-Veterinary Committee on Trauma Registry Report 2013-2017. J Vet Emerg Crit Care (San Antonio) 28:497-502
Fox, C K; Kaizer, A M; Ryder, J R et al. (2018) Cardiometabolic risk factors in treatment-seeking youth versus population youth with obesity. Obes Sci Pract 4:207-215
Hager, Keri D; Blue, Heather L; Zhang, Lei et al. (2018) OPIOIDS: cultivating interprofessional collaboration to find solutions to public health problems. J Interprof Care :1-5

Showing the most recent 10 out of 167 publications