Abstract

CPCRA CTU # 60407: Admin Supplement NOT-AI-20-031 & PA-18-591 Principal Investigator: KAN, Virginia L. PROJECT SUMMARY/ABSTRACT The Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) Clinical Trials Unit (CTU) # 60407 is pleased to submit an Administrative Supplement application in response to NOT-AI-20-031 and PA- 18-591 through the George Washington University (GWU), the applicant organization, in collaboration with two affiliated Clinical Research Sites (CRSs). This CTU is led by Virginia L. Kan, MD, Principal Investigator. This supplement will provide funding to expand SARS-CoV-2 testing at the following two CTU-affiliated Clinical Research Sites: Site 01: George Washington University (GWU) CRS # 31608, Washington, DC Site 02: Houston AIDS Research Team (HART) CRS # 31473, Houston, TX

Public Health Relevance

CPCRA CTU # 60407: Admin Supplement NOT-AI-20-031 & PA-18-591 Principal Investigator: KAN, Virginia L. PROJECT NARRATIVE The Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) Clinical Trials Unit (CTU) # 60407 requests Administrative Supplement funding from 1 June 2020 through 30 November 2020 in response to NOT-AI-20-031 and PA-18-591 to support increased access to SARS-CoV-2 testing at the following two affiliated Clinical Research Sites: George Washington University CRS # 31608 in Washington, DC, and Houston AIDS Research Team (HART) CRS # 31473 in Houston, TX.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
3UM1AI069503-14S1
Application #
10166265
Study Section
Program Officer
Castillo, Blanca E
Project Start
2020-06-04
Project End
2020-11-30
Budget Start
2020-06-04
Budget End
2020-11-30
Support Year
14
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
George Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043990498
City
Washington
State
DC
Country
United States
Zip Code
20052

  Publications

MacBrayne, Christine E; Marks, Kristen M; Fierer, Daniel S et al. (2018) Effects of sofosbuvir-based hepatitis C treatment on the pharmacokinetics of tenofovir in HIV/HCV-coinfected individuals receiving tenofovir disoproxil fumarate. J Antimicrob Chemother 73:2112-2119
Tracy, LaRee A; Struble, Kimberly; Firnhaber, Cynthia et al. (2018) Age Differences by Sex in Antiretroviral-Naïve Participants: Pooled Analysis from Randomized Clinical Trials. J Assoc Nurses AIDS Care 29:371-382
Riddler, Sharon A; Zheng, Lu; Durand, Christine M et al. (2018) Randomized Clinical Trial to Assess the Impact of the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01 on HIV-1 Persistence in Individuals on Effective ART. Open Forum Infect Dis 5:ofy242
Kalayjian, Robert C; Albert, Jeffrey M; Cremers, Serge et al. (2018) Women have enhanced bone loss associated with phosphaturia and CD4+ cell restoration during initial antiretroviral therapy. AIDS 32:2517-2524
Gulick, Roy M; Wilkin, Timothy J; Chen, Ying Q et al. (2017) Safety and Tolerability of Maraviroc-Containing Regimens to Prevent HIV Infection in Women: A Phase 2 Randomized Trial. Ann Intern Med 167:384-393
Levy, M E; Greenberg, A E; Hart, R et al. (2017) High burden of metabolic comorbidities in a citywide cohort of HIV outpatients: evolving health care needs of people aging with HIV in Washington, DC. HIV Med 18:724-735
Gulick, Roy M; Wilkin, Timothy J; Chen, Ying Q et al. (2017) Phase 2 Study of the Safety and Tolerability of Maraviroc-Containing Regimens to Prevent HIV Infection in Men Who Have Sex With Men (HPTN 069/ACTG A5305). J Infect Dis 215:238-246
Kiser, Jennifer J; Lu, Darlene; Rosenkranz, Susan L et al. (2017) Boceprevir and Antiretroviral Pharmacokinetic Interactions in HIV/HCV Co-infected Persons: AIDS Clinical Trials Group Study A5309s. Drugs R D 17:557-567
Robbins, Gregory K; Cohn, Susan E; Harrison, Linda J et al. (2016) Characteristics associated with virologic failure in high-risk HIV-positive participants with prior failure: a post hoc analysis of ACTG 5251. HIV Clin Trials 17:165-72
Roman Isler, M; Golin, C; Wang, J et al. (2016) Venues for Meeting Sex Partners and Partner HIV Risk Characteristics: HIV Prevention Trials Network (HPTN064) Women's HIV Seroincidence Study (ISIS). AIDS Behav 20:1208-18

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