The AIDS Malignancy Consortium (AMC) was established in 1995 and has been at the forefront of the clinical evaluation of interventions for the treatment and prevention of malignancies in people living with the human immunodeficiency virus (PLWH). AMC also studies the biology of cancers and precancerous lesions in PLWH in the context of its clinical trials, providing new insights on further improving the treatment and prevention of cancer. The AMC has conducted over 100 clinical trials, surveys and laboratory studies involving over 8700 patients with HIV- associated cancers and precancerous lesions since its inception, including application of precision therapeutics and immunotherapy, impacting the standard of care for PLWH and cancer. AMC has established a network of 42 core clinical trial sites in the United States, Africa, and Latin America uniquely qualified carry out its mission, created a network of translational scientists and their research laboratories that support AMC clinical trials, and developed a career enhancement program that has fostered a new generation of physicians and scientists with unique expertise in HIV-associated cancers. Expansion of AMC to clinical trials sites in sub- Saharan Africa and Latin America is designed to address regions of the world where the epidemic of HIV and cancer has grown substantially, thereby amplifying the potential clinical impact of its work to a global scale. AMC has also actively engaged PLWH and cancer survivors in its scientific planning and community outreach in order to identify the needs of the community, and disseminate information about AMC and its completed and ongoing research. The participation of many of the key clinicians and clinical researchers, laboratory scientists, and community representatives has made AMC the principal clinical trials group in the world dedicated to improving the treatment and prevention of cancers in this population. We propose to continue and expand our domestic and international clinical trials work in these areas, including the ANCHOR trial; ANCHOR is a large randomized study investigating the role of routine screening for and treatment of high-grade anal squamous intraepithelial lesions, with the goal of preventing development of invasive anal cancer and the morbidity and mortality associated with its diagnosis and treatment, thereby establishing new diagnostic and therapeutic paradigm.

Public Health Relevance

Cancer has been recognized as occurring more commonly in people living with human immunodeficiency virus infection (PLWH), and remains a leading cause of morbidity and mortality despite improvements in antiretroviral therapy. The spectrum of these cancers in PLWH is diverse, complex, and challenging to prevent and treat. AMC remains the only organization worldwide solely dedicated to the study, treatment and prevention of cancer in PLWH.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
2UM1CA121947-14
Application #
10084151
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Liddell Huppi, Rebecca
Project Start
2006-08-29
Project End
2025-08-31
Budget Start
2020-09-08
Budget End
2021-08-31
Support Year
14
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Montefiore Medical Center (Bronx, NY)
Department
Type
DUNS #
041581026
City
New York
State
NY
Country
United States
Zip Code
10467
Ellsworth, G B; Lensing, S Y; Ogilvie, C B et al. (2018) A delayed dose of quadrivalent human papillomavirus vaccine demonstrates immune memory in HIV-1-infected men. Papillomavirus Res 6:11-14
Hosseinipour, Mina C; Kang, Minhee; Krown, Susan E et al. (2018) As-Needed Vs Immediate Etoposide Chemotherapy in Combination With Antiretroviral Therapy for Mild-to-Moderate AIDS-Associated Kaposi Sarcoma in Resource-Limited Settings: A5264/AMC-067 Randomized Clinical Trial. Clin Infect Dis 67:251-260
Painschab, Matthew S; Kasonkanji, Edwards; Zuze, Takondwa et al. (2018) Mature outcomes and prognostic indices in diffuse large B-cell lymphoma in Malawi: a prospective cohort. Br J Haematol :
Burkhalter, Jack E; Atkinson, Thomas M; Berry-Lawhorn, J et al. (2018) Initial Development and Content Validation of a Health-Related Symptom Index for Persons either Treated or Monitored for Anal High-Grade Squamous Intraepithelial Lesions. Value Health 21:984-992
Tan, Carlyn Rose C; Barta, Stefan K; Lee, Jeannette et al. (2018) Combination antiretroviral therapy accelerates immune recovery in patients with HIV-related lymphoma treated with EPOCH: a comparison within one prospective trial AMC034. Leuk Lymphoma 59:1851-1860
Ramos, Juan C; Sparano, Joseph A; Rudek, Michelle A et al. (2018) Safety and Preliminary Efficacy of Vorinostat With R-EPOCH in High-risk HIV-associated Non-Hodgkin's Lymphoma (AMC-075). Clin Lymphoma Myeloma Leuk 18:180-190.e2
Ambinder, Richard F (2018) A viral protein kinase drug target for tumors? J Clin Invest 128:2197-2198
Rubinstein, Paul G; Moore, Page C; Rudek, Michelle A et al. (2018) Brentuximab vedotin with AVD shows safety, in the absence of strong CYP3A4 inhibitors, in newly diagnosed HIV-associated Hodgkin lymphoma. AIDS 32:605-611
Gopal, Satish; Gross, Thomas G (2018) How I treat Burkitt lymphoma in children, adolescents, and young adults in sub-Saharan Africa. Blood 132:254-263
Shanbhag, Satish; Ambinder, Richard F (2018) Hodgkin lymphoma: A review and update on recent progress. CA Cancer J Clin 68:116-132

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