We propose to continue the follow-up of the Nurses' Health Study II, a cancer epidemiology cohort of 116,430 women enrolled at ages 25 to 42 years in 1989. The cohort is currently supported as an R0I. Consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The NHSII biorepository includes plasma, red blood cells, white blood cells, and first morning urine samples from 29,611 women; for two thirds of these women we have timed follicular and luteal premenopausal samples. Over 16,000 provided a 2nd blood/urine sample in 2008-11 when the majorities were postmenopausal, and we have cheek cell DNA from an additional 29,859 women. We have collected archival tissue blocks for incident breast and ovarian cancers and melanoma (approximately 70% of requested have been obtained). We have created tissue microarrays for breast cancers that are already being used extensively. Prediagnostic mammograms have been collected for breast cancer cases and controls, as well as pathology material from previous biopsies of benign lesions. The follow-up of the NHSII cohort, conducted every two years, has been high and accounts for 93% of potential person-time. We have nearly complete ascertainment of deaths using the National Death Index and other methods. The NHSII cohort is unique in many ways, as the only large cohort of women enrolled before menopause, with information on smoking, weight, medication use, and medical diagnoses updated every 2 years and information on diet and physical activity updated every four years. Further, we have collected detailed on in utero and infant exposures (from participants' mothers), diet during high school, and other valuable exposure information. This cohort has been highly productive; over 150 papers have been published during the last five years, and the rate of publication is increasingly rapidly. This cohort is a member of the NCI Cohort Consortium, has participated in many collaborative studies, and has an active resource-sharing component. Enhancements of the cohort infrastructure involve assessment of breast tumor DNA methylation and RNA expression and the gut microbiome, and development of software to account for measurement error.

Public Health Relevance

The goal is to continue the follow-up of the NHSII, a cohort of women with repeated, cycle timed biomarkers and measures of diet, physical activity, and other exposures over several decades. Cohort follow-up is reaching the most informative phase and is a unique resource for scientific aims that integrate diet, other lifestyle variables, biomarkers, genetic predisposition and mediating variables in relation to cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
4UM1CA176726-04
Application #
9087172
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Mahabir, Somdat
Project Start
2013-06-01
Project End
2018-05-31
Budget Start
2016-06-01
Budget End
2017-05-31
Support Year
4
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Harvard University
Department
Nutrition
Type
Schools of Public Health
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
Burke, Kristin E; Ananthakrishnan, Ashwin N; Lochhead, Paul et al. (2018) Identification of Menopausal and Reproductive Risk Factors for Microscopic Colitis-Results From the Nurses' Health Study. Gastroenterology 155:1764-1775.e2
Kim, Jihye; Kraft, Peter; Hagan, Kaitlin A et al. (2018) Interaction of a genetic risk score with physical activity, physical inactivity, and body mass index in relation to venous thromboembolism risk. Genet Epidemiol 42:354-365
Timpka, Simon; Stuart, Jennifer J; Tanz, Lauren J et al. (2018) Postpregnancy BMI in the Progression From Hypertensive Disorders of Pregnancy to Type 2 Diabetes. Diabetes Care :
Devore, Elizabeth E; Chang, Shun-Chiao; Okereke, Olivia I et al. (2018) Photoperiod during maternal pregnancy and lifetime depression in offspring. J Psychiatr Res 104:169-175
Dumas, Orianne; Varraso, Raphäelle; Boggs, Krislyn M et al. (2018) Association of hand and arm disinfection with asthma control in US nurses. Occup Environ Med 75:378-381
Li, Wen-Qing; Cho, Eunyoung; Wu, Shaowei et al. (2018) Host characteristics and risk of incident melanoma by Breslow thickness. Cancer Epidemiol Biomarkers Prev :
Huang, Tianyi; Lin, Brian M; Redline, Susan et al. (2018) Type of Menopause, Age at Menopause, and Risk of Developing Obstructive Sleep Apnea in Postmenopausal Women. Am J Epidemiol 187:1370-1379
Reeves, Katherine W; Okereke, Olivia I; Qian, Jing et al. (2018) Depression, Antidepressant Use, and Breast Cancer Risk in Pre- and Postmenopausal Women: A Prospective Cohort Study. Cancer Epidemiol Biomarkers Prev 27:306-314
Harris, H R; Eke, A C; Chavarro, J E et al. (2018) Fruit and vegetable consumption and risk of endometriosis. Hum Reprod 33:715-727
He, Xiaosheng; Wu, Kana; Ogino, Shuji et al. (2018) Association Between Risk Factors for Colorectal Cancer and Risk of Serrated Polyps and Conventional Adenomas. Gastroenterology 155:355-373.e18

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