The Collaborative Human Tissue Network is a continuation of a successful program to increase the supply and quality of human tissues to support research in cancer. The University of Alabama at Birmingham (UAB), as the Southern Division (SD) of the CHTN, has participated effectively in all CHTN operations at the national level since 1987. The policies and guidelines that have been established have resulted in a dependable source for cancer researchers of a wide range of expertly processed, well-characterized and high quality human tissues with associated histopathologic and demographic data. New challenges to biorepository operations are emerging, however. The current advances in cancer research, including the issues surrounding research into personalized medicine, have resulted in an increase in demand for tissue samples and more complex requests. Concurrently, changes in medical care, such as preoperative therapy, use of high resolution imaging instead of tissue diagnoses, as well as a changing regulatory environment are affecting tissue collections. The leadership team of the SD has taken a proactive stance to meet the future needs of cancer investigators. (1) Enhancement of operations through recruitment of additional participating sites; increased use of archival paraffin blocks for metastatic lesions and untreated primary tumors; use of novel techniques, including nitrocellulose blots, for obtaining aliquots of small tissue specimens; and development of a rapid autopsy program. These are accompanied by increased education of investigators as to use of alternative tissues (e.g., autopsy, paraffin blocks) and to specimen limitations; (2) Enhancement of quality assurance and quality control through participation in external accreditation processes; and (3) Enhancement of the ethical and regulatory stance through expansion of utilization of patient advocates. The informatics system is critical to all biorepository functions and the SD proposes development of an Investigators' IT system that utilizes new-era interoperability and linked big-data systems. It als proposes an increased emphasis on training and proficiency testing in IT systems, coupled with greater utilization of the Web for access to and training in SOPs. The SD reaffirms its commitment to the operations of the CHTN as a whole. In addition to ongoing involvement at the leadership level, it continues significant collaborative efforts with individual divisions, including supplying tissues for microarrays and beta-testing of modifications of the current IT system. Since 2008, the SD has provided 20,287 fresh, frozen and fixed human aliquots to 264 investigators. Notably, within the CHTN network it provides complex specimens including aliquots of tissue processed within 30 minutes of collection; macrodissected paraffin and frozen tissues and mRNA/DNA samples as well as detailed clinical information and follow-up to investigators. It is one of the leading providers of fresh tissue samples and body fluids and the leading provider of samples from African-American patients.

Public Health Relevance

Use of human tissues in research is critical to the development of medical care. This grant focuses on the collection, processing, storage and distribution of human tissues to cancer investigators throughout the United States and Canada. There are multiple participant sites including Northside Hospitals in Atlanta and the University of South Alabama in Mobile. A specific emphasis is the provision of tissue from minorities especially African Americans.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
5UM1CA183728-03
Application #
9036347
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Chuaqui, Rodrigo F
Project Start
2014-04-01
Project End
2019-03-31
Budget Start
2016-04-01
Budget End
2017-03-31
Support Year
3
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Pathology
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Gaston, Sandra M; Grizzle, William E; Rais-Bahrami, Soroush et al. (2018) Nitrocellulose tissue prints: an innovative approach to preparing high quality DNA and RNA from prostate biopsies without compromising the cores for pathology diagnosis. Transl Androl Urol 7:S514-S518
Demark-Wahnefried, Wendy; Rais-Bahrami, Soroush; Desmond, Renee A et al. (2017) Presurgical weight loss affects tumour traits and circulating biomarkers in men with prostate cancer. Br J Cancer 117:1303-1313
Vaklavas, Christos; Blume, Scott W; Grizzle, William E (2017) Translational Dysregulation in Cancer: Molecular Insights and Potential Clinical Applications in Biomarker Development. Front Oncol 7:158
Bhutiani, Neal; Grizzle, William E; Galandiuk, Susan et al. (2017) Noninvasive Imaging of Colitis Using Multispectral Optoacoustic Tomography. J Nucl Med 58:1009-1012
McDaniel, Joy M; Varley, Katherine E; Gertz, Jason et al. (2017) Genomic regulation of invasion by STAT3 in triple negative breast cancer. Oncotarget 8:8226-8238
Kirby, Marie K; Ramaker, Ryne C; Gertz, Jason et al. (2016) RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4. Mol Oncol 10:1169-82
Gaignaux, Amélie; Ashton, Garry; Coppola, Domenico et al. (2016) A Biospecimen Proficiency Testing Program for Biobank Accreditation: Four Years of Experience. Biopreserv Biobank 14:429-439
Otali, D; Fredenburgh, J; Oelschlager, D K et al. (2016) A standard tissue as a control for histochemical and immunohistochemical staining. Biotech Histochem 91:309-26
Grizzle, William E; Otali, Dennis; Sexton, Katherine C et al. (2016) Effects of Cold Ischemia on Gene Expression: A Review and Commentary. Biopreserv Biobank 14:548-558
Seijo, Edward; Lima, Diana; Iriabho, Egiebade et al. (2016) Construction and Validation of a Multi-Institutional Tissue Microarray of Invasive Ductal Carcinoma From Racially and Ethnically Diverse Populations. Cancer Control 23:383-389

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