Alcohol dependence is highly co-morbid with anxiety disorders. Urges to drink are closely correlated with concomitant levels of self-reported anxiety. Substance P is an amino acid peptide which belongs to the neurokinin family. In humans, neurokinins are thought to mediate their effects primarily at neurokinin -1 (NK-1) receptors. Animal studies show that Substance P is released in response to stress and gives rise to behaviors that are thought to represent anxiety. Animal studies also suggest that the NK-1 receptors affect alcohol consumption. The drug used in this study is an NK-1 receptor antagonist. Outcome measures include craving for alcohol and measures of anxiety. To date 26 anxious alcohol dependent patients have been enrolled in the study. Study accrual has been set at 50 patients.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000206-01
Application #
7317772
Study Section
(LCTS)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2006
Total Cost
Indirect Cost
Name
Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code
George, David T; Gilman, Jodi; Hersh, Jacqueline et al. (2008) Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. Science 319:1536-9