We have developed novel chemical derivatization procedures to render biogenic amines lipid soluble and/or electroactive. The derivatives have been extracted into organic solvents and quantified with electrochemical detection. These methods have been applied to quantify serotonin in human and nonhuman primate cerebrospinal fluid and histamine turnover in various nuclei of the rat brain.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000256-01
Application #
4687743
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code