Abstract

To identify alcoholism risk genes, we are collecting and testing for linkage families from three different American Indian populations which are relatively homogeneous and in which alcoholism is highly prevalent. This study also addresses the genetic epidemiology and psychiatry comorbidity of alcoholism in American Indians using structured psychiatric diagnostic interviews of subjects in large families. Studies of Cheyenne and Pima Indians are currently in progress. Two hundred Cheyenne Indian and 350 Pima Indian subjects from single families have clinically evaluated and their cell lines immortalized with a target family size of 600 from each community. At Jemez Pueblo, data and cell lines have been collected for 100 of 200 subjects. A large panel of random polymorphic probes has been typed in Cheyenne alcoholics and controls and genetic linkage analysis is in progress for this group. An analysis of psychiatric comorbidity in Cheyenne and Pima Indian alcoholics and nonalcoholics has been completed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000281-05
Application #
3745242
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
National Institute on Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Landefeld, Clare C; Hodgkinson, Colin A; Spagnolo, Primavera A et al. (2018) Effects on gene expression and behavior of untagged short tandem repeats: the case of arginine vasopressin receptor 1a (AVPR1a) and externalizing behaviors. Transl Psychiatry 8:72
Hong, L E; Yang, X; Wonodi, I et al. (2011) A CHRNA5 allele related to nicotine addiction and schizophrenia. Genes Brain Behav 10:530-5
O'Malley, Stephanie S; Robin, Robert W; Levenson, Aryeh L et al. (2008) Naltrexone alone and with sertraline for the treatment of alcohol dependence in Alaska natives and non-natives residing in rural settings: a randomized controlled trial. Alcohol Clin Exp Res 32:1271-83
Ducci, F; Enoch, M-A; Hodgkinson, C et al. (2008) Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. Mol Psychiatry 13:334-47
Robin, Robert W; Gottesman, Irving I; Albaugh, Bernard et al. (2007) Schizophrenia and psychotic symptoms in families of two American Indian tribes. BMC Psychiatry 7:30
Barnett, Jennifer H; Heron, Jon; Ring, Susan M et al. (2007) Gender-specific effects of the catechol-O-methyltransferase Val108/158Met polymorphism on cognitive function in children. Am J Psychiatry 164:142-9
Oquendo, Maria A; Hastings, Ramin S; Huang, Yung-Yu et al. (2007) Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography. Arch Gen Psychiatry 64:201-8
Clarimon, Jordi; Gray, Rebecca R; Williams, Lindsey N et al. (2007) Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations. Alcohol Clin Exp Res 31:546-54
Enoch, Mary-Anne; Shen, Pei-Hong; Xu, Ke et al. (2006) Using ancestry-informative markers to define populations and detect population stratification. J Psychopharmacol 20:19-26
Enoch, Mary-Anne; Waheed, Juwaria F; Harris, Claudia R et al. (2006) Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indians. Alcohol Clin Exp Res 30:399-406

Showing the most recent 10 out of 34 publications