Abstract

In order to follow-up a linkage finding on chromosome 11p15.5 to alcohol dependence, two short tandem-repeat marker panels for semi-automated fluorescent genotyping containing 15 loci distributed over the distal 20 cM of chromosome 11p15.5 have been created. One panel (six loci) has been typed in approximately 500 psychiatrically-interviewed individuals from a Southwest American Indian tribe. A second panel (nine loci) has been optimized and typing will begin soon. In addition, two coding polymorphisms and one promoter polymorphism at DRD4, a candidate gene for involvement in vulnerability to alcohol dependence, have been typed in order to develop haplotypes at this locus, distal to the short-tandem repeat locus linked in the whole genome linkage scan. Linkage using haplotypes constructed from these markers has confirmed the primary linkage finding in a second panel of Southwest American Indian sib pairs, indicating that a locus contributing to alcohol dependence is in the 11p15.5 region.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000296-05
Application #
6521826
Study Section
(LNG)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Heinz, Andreas; Goldman, David; Gallinat, Jurgen et al. (2004) Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence. Psychopharmacology (Berl) 174:561-70
Gunzerath, Lorraine; Goldman, David (2003) G x E: a NIAAA workshop on gene-environment interactions. Alcohol Clin Exp Res 27:540-62
Hink, Raquel L; Hokanson, John E; Shah, Imran et al. (2003) Investigation of DUSP8 and CALCA in alcohol dependence. Addict Biol 8:305-12
Roy, A; Rylander, G; Forslund, K et al. (2001) Excess tryptophan hydroxylase 17 779C allele in surviving cotwins of monozygotic twin suicide victims. Neuropsychobiology 43:233-6
Malhotra, A K; Goldman, D (2000) The dopamine D(4) receptor gene and novelty seeking. Am J Psychiatry 157:1885-6
Evans, J; Reeves, B; Platt, H et al. (2000) Impulsiveness, serotonin genes and repetition of deliberate self-harm (DSH). Psychol Med 30:1327-34
Rotondo, A; Schuebel, K; Bergen, A et al. (1999) Identification of four variants in the tryptophan hydroxylase promoter and association to behavior. Mol Psychiatry 4:360-8
Han, L; Nielsen, D A; Rosenthal, N E et al. (1999) No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. Biol Psychiatry 45:615-9