Abstract

A method was developed to measure the rate of incorporation of palmitrate from plasma into different brain regions in the awake rat, Jpalm. Furthermore, a theoretical model was developed to calculate Jpalm from data, and to interpret the results. Jpalm did not change with aging in Fischer-344 rats between 3 and 34 months of age, indicating that the rate of turnover of palmitrate-containing brain lipids was unchanged. During development of the rat, Jpalm increased between 15 and 20 days, then fell more than 8 fold to maturity. The time course corresponded to the time course of myelination in the developing brain. Jpalm was found to fall in the pituitary and pineal glands of Brattleboro rats as compared to controls, and to fall in central auditory pathways following damage to the cochlea of rats.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000134-02
Application #
4687909
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Ramadan, Epolia; Basselin, Mireille; Taha, Ameer Y et al. (2011) Chronic valproate treatment blocks D2-like receptor-mediated brain signaling via arachidonic acid in rats. Neuropharmacology 61:1256-64
Rapoport, Stanley I; Ramadan, Epolia; Basselin, Mireille (2011) Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission. Prostaglandins Other Lipid Mediat 96:109-13
Chang, Lisa; Rapoport, Stanley I; Nguyen, Henry N et al. (2009) Acute nicotine reduces brain arachidonic acid signaling in unanesthetized rats. J Cereb Blood Flow Metab 29:648-58
Basselin, Mireille; Chang, Lisa; Chen, Mei et al. (2008) Chronic administration of valproic acid reduces brain NMDA signaling via arachidonic acid in unanesthetized rats. Neurochem Res 33:2229-40
Basselin, Mireille; Villacreses, Nelly E; Lee, Ho-Joo et al. (2007) Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats. Neurochem Res 32:1857-67
Zapata, Agustin; Gonzales, Rueben A; Shippenberg, Toni S (2006) Repeated ethanol intoxication induces behavioral sensitization in the absence of a sensitized accumbens dopamine response in C57BL/6J and DBA/2J mice. Neuropsychopharmacology 31:396-405
DeMar Jr, James C; Lee, Ho-Joo; Ma, Kaizong et al. (2006) Brain elongation of linoleic acid is a negligible source of the arachidonate in brain phospholipids of adult rats. Biochim Biophys Acta 1761:1050-9
Basselin, Mireille; Chang, Lisa; Rapoport, Stanley I (2006) Chronic lithium chloride administration to rats elevates glucose metabolism in wide areas of brain, while potentiating negative effects on metabolism of dopamine D2-like receptor stimulation. Psychopharmacology (Berl) 187:303-11
Ma, Kaizong; Deutsch, Joseph; Villacreses, Nelly E et al. (2006) Measuring brain uptake and incorporation into brain phosphatidylinositol of plasma myo-[2H6]inositol in unanesthetized rats: an approach to estimate in vivo brain phosphatidylinositol turnover. Neurochem Res 31:759-65
Bhattacharjee, Abesh K; Chang, Lisa; White, Laura et al. (2006) D-Amphetamine stimulates D2 dopamine receptor-mediated brain signaling involving arachidonic acid in unanesthetized rats. J Cereb Blood Flow Metab 26:1378-88

Showing the most recent 10 out of 43 publications