Cerebrospinal Fluid Markers Of Aging And Brain Disease

Rapoport, Stanley I.

Abstract

A model is being developed to estimate brain delivery of homovanillic acid to cerebrospinal fluid (CSF) in humans, when taking into account the lumbar CSF concentrations of homovanillic acid and published flow rates. Homovanillic acid is a marker of brain dopamine metabolism.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Intramural Research (Z01)
• Project #: 1Z01AG000139-05
• Application #: 6968660
• Study Section: (BPMS)
• Support Year: 5
• Fiscal Year: 2004

Institution

• Name: Aging
• Country: United States

Publications

Rapoport, Stanley I; Schapiro, Mark B; May, Conrad (2004) Reduced brain delivery of homovanillic acid to cerebrospinal fluid during human aging. Arch Neurol 61:1721-4

Buerger, Katharina; Zinkowski, Raymond; Teipel, Stefan J et al. (2003) Differentiation of geriatric major depression from Alzheimer's disease with CSF tau protein phosphorylated at threonine 231. Am J Psychiatry 160:376-9

Bosetti, Francesca; Brizzi, Francesca; Barogi, Silvia et al. (2002) Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease. Neurobiol Aging 23:371-6

Tendi, Elisabetta A; Bosetti, Francesca; Dasgupta, S Fenella et al. (2002) Ginkgo biloba extracts EGb 761 and bilobalide increase NADH dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells. Neurochem Res 27:319-23

Buerger, Katharina; Zinkowski, Raymond; Teipel, Stefan J et al. (2002) Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231. Arch Neurol 59:1267-72

DasGupta, S F; Rapoport, S I; Gerschenson, M et al. (2001) ATP synthesis is coupled to rat liver mitochondrial RNA synthesis. Mol Cell Biochem 221:3-10

Bosetti, F; Solaini, G; Tendi, E A et al. (2001) Mitochondrial cytochrome c oxidase subunit III is selectively down-regulated by aluminum exposure in PC12S cells. Neuroreport 12:721-4

Hampel, H; Buerger, K; Kohnken, R et al. (2001) Tracking of Alzheimer's disease progression with cerebrospinal fluid tau protein phosphorylated at threonine 231. Ann Neurol 49:545-6

Rapoport, S I (2001) Advances in osmotic opening of the blood-brain barrier to enhance CNS chemotherapy. Expert Opin Investig Drugs 10:1809-18