This is a new project that is aimed at defining insulin resistance to the aging process with the long term goals of developing therapeutic interventions. Synthetic peptides have been made based on the sequence of the insulin receptor beta-subunit in an attempt to prepare an affinity matrix suitable for the purification and characterization of tyrosine protein phosphatase activity that has high specificity toward the insulin receptor. The significance of the project lies in the identification of such insulin receptor-specific phosphatase(s) in intact cell, as well as in the characterization of insulin resistance secondary to variation phosphatase activity.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000213-01
Application #
3802217
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code