Abstract

This year saw the completion and publication of a genome wide association analysis in Alzheimers disease, this work involved generation and analysis of more than 1/2 billion genotypes; and these analyses have now bee released into the public doamin. This work showed elegantly that the APO E locus is the single over-riding common genetic risk factor for Alzheimers disease. Subseqyuent analysis revealed a potential role for genetic variability in GAB2-A as a novel risk factor in Alzheimers disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000950-06
Application #
7592079
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2007
Total Cost
$592,813
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Sassi, Celeste; Nalls, Michael A; Ridge, Perry G et al. (2018) Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. Neurobiol Aging 66:179.e17-179.e29
Chaudhury, Sultan; Patel, Tulsi; Barber, Imelda S et al. (2018) Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer's disease. Neurobiol Aging 62:244.e1-244.e8
Patel, T; Brookes, K J; Turton, J et al. (2017) Whole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease. Neuropathol Appl Neurobiol :
Mapstone, Mark; Lin, Feng; Nalls, Mike A et al. (2017) What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease. Neurobiol Aging 51:148-155
Sassi, Celeste; Ridge, Perry G; Nalls, Michael A et al. (2016) Influence of Coding Variability in APP-A? Metabolism Genes in Sporadic Alzheimer's Disease. PLoS One 11:e0150079
Sassi, Celeste; Nalls, Michael A; Ridge, Perry G et al. (2016) ABCA7 p.G215S as potential protective factor for Alzheimer's disease. Neurobiol Aging 46:235.e1-9
Escott-Price, Valentina; International Parkinson's Disease Genomics Consortium; Nalls, Mike A et al. (2015) Polygenic risk of Parkinson disease is correlated with disease age at onset. Ann Neurol 77:582-91
Peuralinna, Terhi; Myllykangas, Liisa; Oinas, Minna et al. (2015) Genome-wide association study of neocortical Lewy-related pathology. Ann Clin Transl Neurol 2:920-31
Sassi, Celeste; Guerreiro, Rita; Gibbs, Raphael et al. (2014) Investigating the role of rare coding variability in Mendelian dementia genes (APP, PSEN1, PSEN2, GRN, MAPT, and PRNP) in late-onset Alzheimer's disease. Neurobiol Aging 35:2881.e1-2881.e6
Sassi, Celeste; Guerreiro, Rita; Gibbs, Raphael et al. (2014) Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease. Neurobiol Aging 35:2422.e13-6

Showing the most recent 10 out of 98 publications