ACCORD-MIND is funded through an intra-agency agreement between NHLBI and NIA. It is a sub-study nested within the randomized factorial clinical trial - Action to Control Cardiovascular Risk in Diabetics (ACCORD). ACCORD evaluates whether more intensive glucose, blood pressure and lipid management can reduce cardiovascular disease in people with diabetes. ACCORD-MIND is designed to test in a sub-sample of ACCORD participants, whether the intensive interventions can also reduce the rates of cognitive decline and structural brain change. The overall interventions in the ACCORD trial include interventons for glycemic control, HDL-C levels, and blood pressure.? ? Participants in ACCORD-MIND were already randomly assigned to the ACCORD treatment groups. Brain outcomes are assessed with tests of cognitive function (memory and perceptual speed) and MRI scans of brain structure. The cognitive testing is performed in clinics located within six ACCORD networks (Southeast, Northeast, Minnesota-Iowa, Western, Ohio, and Canadian), and the MRI in 4 of the networks. Cognitive testing is performed at the baseline visit, and then 20 and 40 months thereafter; MRIs are acquired at baseline and 40 mos follow-up. ? ? Baseline recruitment for the ACCORD-MIND study is now complete; a total of 2977 persons were tested and 630 MRIs acquired. Currently the first follow-up exam is underway. As of October 2, 2006, a total of 95% of those eligible have been retested, with <1% needing an interview via telephone. ? ? In addition, several studies have been undertaken to examine the association of diabetes to brain aging.
| Launer, Lenore J; Hughes, Timothy M; White, Lon R (2011) Microinfarcts, brain atrophy, and cognitive function: the Honolulu Asia Aging Study Autopsy Study. Ann Neurol 70:774-80 |
| Korf, Esther S C; White, Lon R; Scheltens, Ph et al. (2006) Brain aging in very old men with type 2 diabetes: the Honolulu-Asia Aging Study. Diabetes Care 29:2268-74 |
