Treatment with non-toxic monophosphoryl lipid A (MPL), derived from a polysaccharide deficient heptoseless Re-mutant of Salmonella typhimurium was found to inactivate suppressor T cell activity as evidenced by a decrease in the degree of low-dose immunological paralysis expressed and an increase in the magnitude of the antibody response to Type III pneumococcal polysaccharide (SSS- III). The effect produced, which could not be attributed to the polyclonal activation of immune B cells by MPL, were dependent upon the dose of MPL used, as well as the time when MPL was given relative to low-dose priming or immunization with SSS-III. Neither amplifier nor helper T cell activity was decreased by treatment with the same--or larger--doses of MPL.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000144-25
Application #
3818115
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
25
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code