Abstract

Trials of two new drugs, invermectin (Phase IIa) and CGP-20376 (Phase I), are being initiated in collaboration with investigators from Madras India for patients with bancroftian filariasis. Since bronchoalveolar lavage studies on patients with tropical pulmonary eosinophilia show persistent alveolitis despite standard therapy with diethylcarbamazine (DEC), a trial comparing long-term DEC or DEC plus steroids with standard therapy has commenced. Clinical evaluation of Peace Corps Volunteers working in Central/West Africa indicates that when such expatriates enter Loa loa endemic areas, they become immunologically hypersensitive to the parasite and often develop severe clinical symptoms. To develop means for protecting such individuals from infection, a double-blind trial of prophylactic weekly DEC is now in its second year.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000439-01
Application #
4688548
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Cirino, Christopher M; Leitman, Susan F; Williams, Esther et al. (2008) Transfusion-associated babesiosis with an atypical time course after nonmyeloablative transplantation for sickle cell disease. Ann Intern Med 148:794-5
Frances, Stephen P; Baade, Lisa M; Kubofcik, Joseph et al. (2008) Seroconversion to filarial antigens in Australian defence force personnel in Timor-Leste. Am J Trop Med Hyg 78:560-3
Kim, Yae-Jean; Dale, Janet K; Noel, Pierre et al. (2007) Eosinophilia is associated with a higher mortality rate among patients with autoimmune lymphoproliferative syndrome. Am J Hematol 82:615-24
Klion, Amy D; Robyn, Jamie; Maric, Irina et al. (2007) Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing. Blood 110:3552-6
Maric, Irina; Robyn, Jamie; Metcalfe, Dean D et al. (2007) KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities. J Allergy Clin Immunol 120:680-7
Lipner, Ettie M; Law, Melissa A; Barnett, Elizabeth et al. (2007) Filariasis in Travelers Presenting to the GeoSentinel Surveillance Network. PLoS Negl Trop Dis 1:e88
Dicko, Alassane; Sagara, Issaka; Diemert, David et al. (2007) Year-to-year variation in the age-specific incidence of clinical malaria in two potential vaccine testing sites in Mali with different levels of malaria transmission intensity. Am J Trop Med Hyg 77:1028-33
Klion, Amy D (2007) Approach to the therapy of hypereosinophilic syndromes. Immunol Allergy Clin North Am 27:551-60
Nutman, Thomas B (2007) Evaluation and differential diagnosis of marked, persistent eosinophilia. Immunol Allergy Clin North Am 27:529-49
Lipner, Ettie M; Gopi, P G; Subramani, R et al. (2006) Coincident filarial, intestinal helminth, and mycobacterial infection: helminths fail to influence tuberculin reactivity, but BCG influences hookworm prevalence. Am J Trop Med Hyg 74:841-7

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