A major research obstacle in the study of the Norwalk-like human caliciviruses has been our inability to grow them in cell culture. The growth of Norwalk virus (NV) in cell culture would be a major advance in studies that address: (1) antigenic relationships among human caliciviruses; (2) identification of immune correlates of resistance to illness; (3) viral replication strategies of the Caliciviridae, unique single-stranded RNA viruses that have not been well characterized; (4) control of epidemic gastroenteritis by treatment or immunization; and (5) the epidemiology of human caliciviruses and the extent of their role in human diarrheal disease. Thus, a major goal of this project is to develop systems for study of the basic molecular biology and replication of these fastidious human pathogens.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000642-06
Application #
6160674
Study Section
Special Emphasis Panel (LID)
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1997
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code