Therapeutic Studies in Recently Acquired HIV Infection

Dybul, Mark

Abstract

Although highly active antiretroviral therpay (HAART) has been successful in controlling plasma HIV levels it has not been able to eradicate virus from reservoir sites. In addition, the effects of HAART on immunologic restoration remains incomplete. To address the deficiencies, interleukin-2 (IL-2) is being studied for its potential role in supplementing HAART. This study examines the effect of HAART alone versus HAART plus IL-2 on the resting CD4+ T cell reservoir and on certain components of the immune system in patients with recently acquired HIV infection.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Intramural Research (Z01)
• Project #: 1Z01AI000849-02
• Application #: 6431715
• Study Section: Immunological Sciences Study Section (IMS)
• Support Year: 2
• Fiscal Year: 2000

Institution

• Name: Niaid Extramural Activities
• Country: United States

Publications

Chun, T W; Justement, J S; Moir, S et al. (2001) Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: implications for the development of therapeutic strategies. Proc Natl Acad Sci U S A 98:253-8

Dybul, M; Mercier, G; Belson, M et al. (2000) CD40 ligand trimer and IL-12 enhance peripheral blood mononuclear cells and CD4+ T cell proliferation and production of IFN-gamma in response to p24 antigen in HIV-infected individuals: potential contribution of anergy to HIV-specific unresponsiveness. J Immunol 165:1685-91

Chun, T W; Engel, D; Mizell, S B et al. (1999) Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy. Nat Med 5:651-5

McDyer, J F; Dybul, M; Goletz, T J et al. (1999) Differential effects of CD40 ligand/trimer stimulation on the ability of dendritic cells to replicate and transmit HIV infection: evidence for CC-chemokine-dependent and -independent mechanisms. J Immunol 162:3711-7