Mechanisms of Cellular Transformation by HTLV-1

Jeang, Kuan-Teh

Abstract

This project focuses on basic cellular transformation events as related to HTLV-I. For this purpose, we study cellular genetic integrity, cell cycle progression and the checkpoints within a cell that guards normal cellular division. Some notable scientific advances from our research program in 2006-2007 include: 1) Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 tax; 2) Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice; and 3) Histone Acetyltransferase hALP and Nuclear Membrane Protein hsSUN1 Function in De-condensation of Mitotic Chromosomes.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Intramural Research (Z01)
• Project #: 1Z01AI001023-01
• Application #: 7592374
• Support Year: 1
• Fiscal Year: 2007
• Total Cost: $904,857

Institution

• Name: National Institute of Allergy and Infectious Diseases
• Country: United States

Publications

Peloponese Jr, Jean-Marie; Yasunaga, Junichiro; Kinjo, Takao et al. (2009) Peptidylproline cis-trans-isomerase Pin1 interacts with human T-cell leukemia virus type 1 tax and modulates its activation of NF-kappaB. J Virol 83:3238-48

Iwanaga, Yoichi; Chi, Ya-Hui; Miyazato, Akiko et al. (2007) Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice. Cancer Res 67:160-6

Chi, Ya-Hui; Jeang, Kuan-Teh (2007) Aneuploidy and cancer. J Cell Biochem 102:531-8

Matsuoka, Masao; Watanabe, Toshiki; Kannagi, Mari et al. (2007) Meeting report on the 13th International Conference on Human Retrovirology: human T-cell leukemia virus research 30 years after adult T-cell leukemia. Cancer Res 67:10638-41

Chi, Ya-Hui; Haller, Kerstin; Peloponese Jr, Jean-Marie et al. (2007) Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes. J Biol Chem 282:27447-58

Matsuoka, Masao; Jeang, Kuan-Teh (2007) Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer 7:270-80

Chin, King-Tung; Chun, Abel C S; Ching, Yick-Pang et al. (2007) Human T-cell leukemia virus oncoprotein tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1. Cancer Res 67:1072-81

Sheleg, Sergey V; Peloponese, Jean-Marie; Chi, Ya-Hui et al. (2007) Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 Tax. J Virol 81:7894-901

Peloponese Jr, Jean-Marie; Kinjo, Takao; Jeang, Kuan-Teh (2007) Human T-cell leukemia virus type 1 Tax and cellular transformation. Int J Hematol 86:101-6

Osaki, Mitsuhiko; Inoue, Toshiaki; Yamaguchi, Shigeyuki et al. (2007) MAD1 (mitotic arrest deficiency 1) is a candidate for a tumor suppressor gene in human stomach. Virchows Arch 451:771-9