Adenovirus vectors have shown promise for vaccines, but one key hurdle is preexisting immunity to these viruses in humans. The VRC has been investigating the use of DNA priming and the use of alternate adenoviral serotypes or modified adenoviral vectors to overcome prior immunity. During the past year, the VRC has evaluated various modifications to Adenovirus serotype 5 and 35 as well as Ad 14, 26 and 28 vectors to determine if they remain immunogenic while reducing the impact of prior exposure to Ad5. The VRC conducted immunogenicity tests that was able to induce an effective immune response despite pre-exposure to Ad5. Several of these vectors are being further tested to evaluate their potential use in clinical trials.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI005001-07
Application #
7732729
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2008
Total Cost
$1,069,851
Indirect Cost
City
State
Country
United States
Zip Code
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