Abstract

We have yet to fully define the immune responses associated with immunologic control of HIV replication. To develop an effective vaccine, we need to better understand the responses that may be controlling HIV, and why these defenses might fail. This study examines the T cell immune responses to HIV in naturally-infected subjects. It compares these responses with those generated against other viruses and non-viral pathogens in order to determine mechanisms of success or failure of an immune response.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI005014-02
Application #
6822213
Study Section
(IMC)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2003
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Koup, Richard A; Lamoreaux, Laurie; Zarkowsky, David et al. (2009) Replication-defective adenovirus vectors with multiple deletions do not induce measurable vector-specific T cells in human trials. J Virol 83:6318-22
Duvall, Melody G; Lore, Karin; Blaak, Hetty et al. (2007) Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection. J Virol 81:13486-98
Duvall, Melody G; Jaye, Assan; Dong, Tao et al. (2006) Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection. J Immunol 176:6973-81
Brenchley, Jason M; Ruff, Laura E; Casazza, Joseph P et al. (2006) Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo. J Virol 80:6801-9
Lore, Karin; Smed-Sorensen, Anna; Vasudevan, Jayanand et al. (2005) Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cells. J Exp Med 201:2023-33
Smed-Sorensen, Anna; Lore, Karin; Vasudevan, Jayanand et al. (2005) Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells. J Virol 79:8861-9
Ganesh, Lakshmanan; Leung, Kwanyee; Lore, Karin et al. (2004) Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodies. J Virol 78:11980-7
Sugaya, Makoto; Lore, Karin; Koup, Richard A et al. (2004) HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clusters. J Immunol 172:2219-24
Perfetto, Stephen P; Ambrozak, David R; Roederer, Mario et al. (2004) Viable infectious cell sorting in a BSL-3 facility. Methods Mol Biol 263:419-24
Brenchley, Jason M; Hill, Brenna J; Ambrozak, David R et al. (2004) T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis. J Virol 78:1160-8

Showing the most recent 10 out of 15 publications