Abstract

A lack of neutralizing antibodies distinguishes HIV-1 from most other viral pathogens and is responsible to a large degree for the ability of HIV-1 to maintain a persistent infection. A few monoclonal antibodies have been isolated that are broadly neutralizing. We have used X-ray crystallography to investigate the epitopes of broadly neutralizing antibodies and their mechanisms of neutralization.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI005022-05
Application #
7299826
Study Section
(SBS)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2006
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Kong, Leopold; Sattentau, Quentin J (2012) Antigenicity and Immunogenicity in HIV-1 Antibody-Based Vaccine Design. J AIDS Clin Res S8:3
Davis, Katie L; Bibollet-Ruche, Frederic; Li, Hui et al. (2009) Human immunodeficiency virus type 2 (HIV-2)/HIV-1 envelope chimeras detect high titers of broadly reactive HIV-1 V3-specific antibodies in human plasma. J Virol 83:1240-59
Zhou, Tongqing; Xu, Ling; Dey, Barna et al. (2007) Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature 445:732-7
Huang, Chih-Chin; Lam, Son N; Acharya, Priyamvada et al. (2007) Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. Science 317:1930-4
Decker, Julie M; Bibollet-Ruche, Frederic; Wei, Xiping et al. (2005) Antigenic conservation and immunogenicity of the HIV coreceptor binding site. J Exp Med 201:1407-19
Huang, Chih-chin; Tang, Min; Zhang, Mei-Yun et al. (2005) Structure of a V3-containing HIV-1 gp120 core. Science 310:1025-8
Zhou, Tongqing; Hamer, Dean H; Hendrickson, Wayne A et al. (2005) Interfacial metal and antibody recognition. Proc Natl Acad Sci U S A 102:14575-80
Venter, Marietjie; Myers, Timothy G; Wilson, Michael A et al. (2005) Gene expression in mice infected with West Nile virus strains of different neurovirulence. Virology 342:119-40
Huang, Chih-chin; Venturi, Miro; Majeed, Shahzad et al. (2004) Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120. Proc Natl Acad Sci U S A 101:2706-11
Kwong, Peter D (2004) The 447-52D antibody: hitting HIV-1 where its armor is thickest. Structure 12:173-4

Showing the most recent 10 out of 13 publications