A vaccine against SARS coronavirus would be highly significant in preventing future outbreaks of this emerging disease. Genetic vaccines (DNA and adenoviral) expressing various proteins, including spike glycoprotein, envelope, and nucleoprotein. These were tested to determine immune response. Mechanisms of infection and immune correlates of protection were also studied.
| Kong, Wing-pui; Xu, Ling; Stadler, Konrad et al. (2005) Modulation of the immune response to the severe acute respiratory syndrome spike glycoprotein by gene-based and inactivated virus immunization. J Virol 79:13915-23 |
| Yang, Zhi-Yong; Kong, Wing-Pui; Huang, Yue et al. (2004) A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice. Nature 428:561-4 |
| Yang, Zhi-Yong; Huang, Yue; Ganesh, Lakshmanan et al. (2004) pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN. J Virol 78:5642-50 |
