The goal of these studies is to provide insights into the interaction of CCR5-tropic HIV with myeloid dendritic cells (mDCs). The mDCs normally circulate throughout tissues and lymphoid organs, where they capture antigens and process them for presentation to the immune system. Our findings suggest that infection of mDC by CCR5-tropic virus can establish a pool of infected cells that can efficiently transfer virus and at the same time protect virus from antibody neutralization.
| Frymoyer, Adam; Verotta, Davide; Jacobson, Pamala et al. (2013) Population pharmacokinetics of unbound mycophenolic acid in adult allogeneic haematopoietic cell transplantation: effect of pharmacogenetic factors. Br J Clin Pharmacol 75:463-75 |
| Ganesh, Lakshmanan; Yoshimoto, Takanobu; Moorthy, Narayani C et al. (2006) Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis. Mol Cell Biol 26:3864-74 |
