Mycoplasma hominis strain 1620, isolated fro the synovial fluid of a chronically infected spetic arthritis patient, has been the primary strain under study to determine the types of receptors used for colonization of the host. We have found that M. hominis binds only to sulfatide or sulfated glycolipids and to no other glycolipid or glycoprotein tested. M. hominis colonizes the human urogenital tract. Both male and female tracts possess a preponderance of sulfated glycolipids on the surface of the tissues. It is therefore reasonable that the mycoplasma make use of this prevalent compound as its receptor for attachment.

Agency
National Institute of Health (NIH)
Institute
Food and Drug Administration (FDA)
Type
Intramural Research (Z01)
Project #
1Z01BA006011-02
Application #
3792351
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost