The nature of receptors on mammalian cells for B. pertussis and its adhesins is currently being investigated. Results indicate that virulent strains of B. pertussis can bind to certain glycolipids present in lung tissues. The structure of these glycolipids is being investigated as is the nature of the bacterial adhesins mediating this interaction. The role of integrins as receptors for the RGD-containing B. pertussis proteins, pertactin and FHA, is also under investigation.

Agency
National Institute of Health (NIH)
Institute
Food and Drug Administration (FDA)
Type
Intramural Research (Z01)
Project #
1Z01BA007018-02
Application #
3804654
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost