A novel genetic method MALD has been proposed and implemented in the laboratory which provides a population- and patient cohort-based approach for disease gene identification. The method uses genetic markers with significant allele frequency differences between racial groups that we have developed. In combination with a population that has a recent history of admixture one can identify novel disease genes underlying racial disparities in patient cohorts. This methodology is particularly appropriate for diseases where collecting large families for linkage analysis is difficult or where disease onset involves exposure to a common environmental or infectious agent. We have been collecting and analyzing samples from African American patients for hepatitis C virus (HCV) clearance, HIV-1/AIDS, focal segmental glomerulosclerosis, and end-stage renal disease. These diseases are currently ongoing MALD mapping, statistical analysis and fine mapping of signals for gene localization and identification.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC005800-14
Application #
7732904
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2008
Total Cost
$123,133
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Chretien, J-P; Coresh, J; Berthier-Schaad, Y et al. (2006) Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein(a) level elevation in African Americans compared with European Americans. J Med Genet 43:917-23
Smith, Michael W; O'Brien, Stephen J (2005) Mapping by admixture linkage disequilibrium: advances, limitations and guidelines. Nat Rev Genet 6:623-32
Smith, Michael W; Patterson, Nick; Lautenberger, James A et al. (2004) A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet 74:1001-13